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This paper examines the long and short term co-variability of QT and RR intervals for diabetic patients to explore if the QT-RR co-variability could yield a noble index for the stratification of clinical severity of the disease. Twenty four hour Holter ECG recordings are made for 19 type 2 diabetic (T2DM) patients and 25 normal subjects. RR and QT intervals are extracted from ECG signals sampled at...
Diabetic retinopathy (DR) is one of the most common causing of vision loss in developed countries. In early stage of DR, some signs like exudates appear in the retinal images. An automatic screening system must be capable to detect these signs properly so that the treatment of the patients may begin in time. The appearance of exudates shows a rich variety regarding their shape and size making automatic...
Various methods for detecting optic disc and macula in fundus images have been developed. Our aim is to propose a fairly easy method for detecting both features jointly. This is achieved by first correcting inhomogenous luminosity using a polynomial approximation of the background of the images. Secondly, the use of the cross-correlation in the frequency domain between the images and a steerable template...
Diabetic retinopathy (DR) is a visual complication of diabetes, which has become one of the leading causes of preventable blindness in the world. Exudate detection is an important problem in automatic screening systems for detection of diabetic retinopathy using color fundus photographs. In this paper, we present a method for detection of exudates in color fundus photographs, which combines several...
The biomedical community has shown a continued interest in automated detection of Diabetic Retinopathy (DR), with new imaging techniques, evolving diagnostic criteria, and advancing computing methods. Existing state of the art for detecting DR-related lesions tends to emphasize different, specific approaches for each type of lesion. However, recent research has aimed at general frameworks adaptable...
We investigate the maximal performance that can be measured for automated binary decision systems in terms of area under the ROC curve (AUC), against a reference standard provided by human readers. The goal is to determine the required characteristics of the reference standard to assess and compare automated decision systems with a given degree of confidence, or, to determine what degree of confidence...
Hypoglycemia is a common side-effect of insulin therapy for patients with type 1 diabetes mellitus (T1DM) and is the major limiting factor to maintain tight glycemic control. The deficiency in glucose counter-regulation may even lead to severe hypoglycaemia. It is always threatening to the well-being of patients with T1DM since more severe hypoglycemia leads to seizures or loss of consciousness and...
Foot problem diagnosis is often made by using pressure mapping systems, unfortunately located and used in the laboratories. In the context of e-health and telemedicine for home monitoring of patients having foot problems, our focus is to present an acceptable system for daily use. We developed an ambulatory instrumented insole using 3 pressures sensors to visualize plantar pressure cartographies....
We present a novel concept for ophthalmic glucose sensing using a biosensing system that consists of plasmonic dipole metamaterial covered by a layer of functionalized hydrogel. The metamaterial together with the hydrogel can be integrated into a contact lens. This optical sensor changes its properties such as reflectivity upon the ambient glucose concentration, which allows in situ measurements in...
Gathering experimental data to test computer methods developed during a research is a hard work. Nowadays, some databases have been stored online that can be freely downloaded, however there is not a wide range of databases yet and not all pathologies are covered. Researchers with low resources are in need of more data they can consult for free. To cope with this we present an on-line portal containing...
We propose WELCOME, an innovative integrated care platform using wearable sensors and smart cloud computing for Chronic Obstructive Pulmonary Disease (COPD) patients with co-morbidities. WELCOME aims to bring about a change in the reactive nature of the management of chronic diseases and its comorbidities, in particular through the development of a patient centred and proactive approach to COPD management...
The purpose of this study is to develop smart equipment to quantify plantar tactile sensibility for the early diagnosis and tracking of peripheral neuropathy caused by diabetes mellitus. In this paper, we offer a new testing system that is composed of a plantar tactile stimulation platform with a small moving contactor to stretch the skin tangentially, a response switch for each tactile stimulus,...
The recent developments of m-health technologies particularly in the developing world are increasing sharply due to the importance and accelerated adoption of these technologies in the developing countries. However, there are few if any studies on the effectiveness of mobile health in post conflict regions especially in the Middle East region. In this paper we describe the design, implementation and...
Development of a novel method for non-invasive measurement of blood glucose concentration using smartphone is discussed. Our research work has three major contributions to society and science. First, we modified and extended the Beer-Lambert's law in physics to accommodate for multiple wavelengths. This extension can aid researchers who wish to perform optical spectroscopy. Second, we successfully...
Insulin sensitivity is determined using direct or indirect methods. Indirect methods are less invasive than direct methods, but have lower accuracy. The accuracy is set through the Spearman's rank correlation coefficient between the indirect method and a direct method. Since the set of parameters of each indirect method has been set empirically, different values of insulin sensitivity have been reported...
One of the difficult of the hands peripheral neuropathy screening uncertainty is that the current diagnosis is based not on assessments obtained by accurate and repeatable devices, but mostly on the clinical examination. So, in this paper the authors present a tactile pins-array scale determined with well-defined parameters assessed by non-invasive DITA device (Dynamic Investigation Test-rig on hAptics)...
In diabetic foot, the occurrence of an ulcer is often associated with hyperthermia. Hyperthermia is defined as a temperature greater than 2.2ºC in a given region of one of the foot compared to the temperature of the same region of the contralateral foot. Unfortunately, hyperthermia is not yet assessed in current diabetic foot therapy. In this paper, we propose an easy way to detect a possible hyperthermia...
Treatment of type 1 diabetes consists of maintaining postprandial normoglycemia using the correct prandial insulin dose according to food intake. Nonetheless, it is hardly achieved in practice, which results in several diabetes-related complications. In this study we present a feedforward plus feedback blood glucose control system that considers the glycemic index of foods. It consists of a preprandial...
Healthcare costs in the US are among the highest in the world. Chronic diseases such as diabetes significantly contribute to these extensive costs. Despite technological advances to improve sensing and actuation devices, we still lack a coherent theory that facilitates the design and optimization of efficient and robust medical cyber-physical systems for managing chronic diseases. In this paper, we...
Correct predictions of future blood glucose levels in individuals with Type 1 Diabetes (T1D) can be used to provide early warning of upcoming hypo-/hyperglycemic events and thus to improve the patient's safety. To increase prediction accuracy and efficiency, various approaches have been proposed which combine multiple predictors to produce superior results compared to single predictors. Three methods...
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