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Falls are a major cause of death and morbidity in older adults. In recent years many researchers have examined the role of wearable inertial sensors (accelerometers and/or gyroscopes) to automatically detect falls. The primary goal of such fall monitors is to alert care providers of the fall event, who can then commence earlier treatment. Although such fall detection systems may reduce time until...
Lateral Inhibition (LI) is a widely conserved patterning mechanism in biological systems across species. Distinct from better-known Turing patterns, LI depend on cell-cell contact rather than diffusion. We built an in silico genetic circuit model to analyze the dynamic properties of LI. The model revealed that LI amplifies differences between neighboring cells to push them into opposite states, hence...
This paper proposes an automatic method for the detection of lumen contours in intravascular OCT images with guide wire shadow artifacts. This algorithm is divided into five main procedures: pre-processing, an Otsu binarization approach, an intensity curve approach, a lumen contour position correction, and image reconstruction and contour extraction. The 30 IVOCT images from six anonymous patients...
One to five transvaginal ultrasound scans were taken of 63 women to estimate the microstructural changes in cervix using ultrasonic attenuation. Spectral log difference algorithm showed a clear decrease in attenuation as the time to delivery comes closer. The decrease in attenuation occurs earlier in preterm birth compared to full term birth which can be used as a predictor for preterm birth. Attenuation...
Rotary blood pumps (RBPs) have a low sensitivity to preload changes when run at constant speed, which can lead to harmful ventricular suction events. Therefore a control mechanism is needed to adjust RBP speed in response to patient demand, but an appropriate response time for physiological control strategies to these changes in patient demand has not been determined. This paper aims to evaluate the...
MicroRNAs play an important role in regulation of gene expression, but still detection of their targets remains a challenge. In this work we present a supervised regulatory network inference method with aim to identify potential target genes (mRNAs) of microRNAs. Briefly, the proposed method exploiting mRNA and microRNA expression trains Random Forests on known interactions and subsequently it is...
In robot-assisted needle-based medical procedures, path planning for a flexible needle is challenging with regard to time consumption and searching robustness for the solution due to the nonholonomic motion of the needle tip and the presence of anatomic obstacles and sensitive organs in the intended needle path. We propose a novel and fast path planning algorithm for a robot-assisted active flexible...
Properties of the neural responses to electrical stimulus pulses delivered at various inter-pulse intervals were examined in the visual cortices of mice in vivo, with utilizing the voltage-sensitive dye imaging technique. Our experimental results provided the relationships between the inter-pulse intervals and the stimulus-evoked transient depolarizations, which may offer insight into the design of...
Transcranial direct current stimulation (tDCS) has been used to affect the excitability of neurons within the cerebral cortex. Improvements in motor learning have been found in multiple studies when tDCS was applied to the motor cortex during or before task learning is performed. The application of tDCS to motor imagery, a cognitive task showing activation in similar areas to motor execution, has...
Brain is an electrochemical system and recent studies suggest simultaneous measurement of interrelated brain's electrical and neurochemical activity may lead to better understanding of brain function in addition to developing optimal neural prosthetics. By exploiting opamp Time-sharing technique to minimized power dissipation and silicon area, we have fabricated a power efficient implantable CMOS...
Nocturia is a widespread condition where patients need to micturate frequently during the nighttime. In order to define treatment and measure therapeutic success in nocturia, questionnaires are traditionally used for ambulatory assessment. However, questionnaires were reported to suffer from compliance, embarrassment and subjective bias. An automatic sensor-based system for quantification of nighttime...
A Device to detect for the bladder which is full with urine is designed. The device can measure bladder pressure. The pressure signals are processed. When the pressure exceeds 40cm water column, Pressure signal exceeds a fixed voltage. At the same time, Oscillator sends a signal and the signal transmits to the body surface. The receiver accepts the oscillating signal. Then, the alarm alerts. Liquid...
Resistive loading affects the breathing pattern and causes an increase in negative intrathoracic pressure. The aim of this paper was to study the influence inspiratory and expiratory loading on cardio-respiratory interaction. We recorded electrocardiogram (ECG) and respiratory inductance plethysmogram (RIP) in 11 healthy male subjects under normal and resistive loading conditions. The R-R time series...
Recent advances in analysis of fMRI have established the existence of functional sub-networks in the human brain that are active during the performance of visual, motor, language, and other tasks. We describe two computational methods of delineating functional sub-networks that are active when an individual performs an approach-avoidance paradigm. The paradigm consisted of presentation of images of...
Solid tumors have chaotic organization of blood vessels, disruptive nerve paths and muscle fibers that result in a hostile and heterogeneous microenvironment. These tumor regions are often hypoxic and resistant to radiation therapy. The knowledge of partial pressure of oxygen concentration (pO2), in conjunction with the information about tissue organization, can predict tissue health and may eventually...
It is estimated that Autism Spectrum Disorder (ASD) affects 1 in 68 children. Early identification of an ASD is exceedingly important to the introduction of an intervention. We are developing a robot-assisted approach that will serve as an improved diagnostic and early intervention tool for children with autism. The robot, named PABI® (Penguin for Autism Behavioral Interventions), is a compact humanoid...
In this paper we present a new method for passively measuring walking speed using a small array of radio transceivers positioned on the walls of a hallway within a home. As a person walks between a radio transmitter and a receiver, the received signal strength (RSS) detected by the receiver changes in a repeatable pattern that may be used to estimate walking speed without the need for the person to...
Perinatal hypoxia is a major cause of brain injury in preterm babies. Thus, neuro-protective treatments play a pivotal role during the first 6–8 hours post hypoxic-ischemic insult. However, at present it is not possible to determine which infants are suffering from hypoxic ischemia. Recent investigations suggest that there are high frequency micro-scale transients exist in the first 6–8 hours of a...
Current electronic noses, or e-noses, that employ insect odorant receptors (Ors) as their sensory front end are potentially limited by the fact that the Ors come from a single species. In addition, a realistic e-nose also demands low numbers of Ors at its sensory front end due to the difficulties of receptor/sensor integration and functionalisation. In this work, we report the first investigations...
This work investigates phase synchrony as a neuro-marker for the identification of two brain states: coma and quasi-brain-death. Scalp electroencephalography (EEG) data of 34 patients were recorded in an intensive care unit (ICU), with 17 recordings for patients in a coma state, and 17 recordings for patients in a quasi-brain-death state. Phase synchrony was used for feature extraction from EEG recording...
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