The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Accurate diagnosis of non-alcoholic steatohepatitis (NASH) is a critical issue in current clinical practice. Non-invasive diagnosis of NASH can be achieved by quantitative ultrasound (QUS), which requires a detailed understanding tissue-specific acoustic microstructure at cellular scale (i.e., 10 μm). Therefore, QUS methods would benefit from the knowledge of the acoustic properties of organelles...
For many diseases, such as cancer, simultaneous imaging of different targets can lead to improved diagnosis, better patient prognosis, and therapy guidance/monitoring. PET-CT multiplexing can be cumbersome, costly, and involve radiation exposure. Other modalities such as fluorescent imaging lack clinical and pre-clinical relevance. Therefore, clinically relevant multiplexed imaging is of interest...
Pulse wave velocity (PWV) is a reliable index of arterial stiffness. To date, reflected pulse wave interference is still a major challenge for regional PWV estimation using ultrasound imaging methods. In this study, a high-resolution Radon transform (HRT) method is proposed to eliminate the reflected wave interferences in PWV estimation.
Ultrafast 3D Doppler imaging can provide volumetric high frame rate and high resolution mapping of the vascular anatomy and function [1]. Current approach relies on the use of matrix arrays connected to high count of electronics channel which remain complex and costly. Row Column Addressed (RCA) approaches have been proposed as a low complexity alternative to matrix probe for imaging of blood flows...
Oxygen microbubbles (OMBs) have recently been used as adjunct treatment for solid tumors. Indeed, their ability to relieve tumor hypoxia was shown to benefit sonodynamic and other treatment outcomes in vivo. However, OMBs are often administered via intratumoral injection, and the effect of repeated OMB injections in tumors has not been investigated. Here we report on the paradoxical finding that daily...
Pancreatic ductal adenocarcinoma (PDA) is one of the most prevalent types of cancer. Studies have shown that PDA treatment with IV administration of gemcitabine (GEM) is inhibited by excessive interstitium and connective tissue (stroma) surrounding the tumor. Ultrasound (US) irradiation combined with drug-loaded polylactic acid (PLA) microbubble contrast agents (MB) may circumvent this through targeted...
Recently, ultrafast Doppler techniques have been proposed for imaging brain and other slow flow targets. These techniques rely on synthetic focusing and the use of large ensemble lengths to separate slow-flow signal from the stationary clutter, but are susceptible to high acoustic and thermal noise. We have recently developed the short-lag angular coherence (SLAC) method, which suppresses the incoherent...
Crohn's disease is a chronic autoimmune disease of the intestinal tract affecting 700,000 people in the United States. The pathology of Crohn's disease is characterized by obstructing intestinal strictures due to inflammation, fibrosis, or a combination of both. The identification of fibrosis in intestinal strictures is critical, as the fibrotic strictures are irreversible and have to be removed surgically...
Phase-change contrast agents (PCCAs) provide advantages over conventional microbubble contrast agents, including increased circulation time and the ability to extravasate from leaky tumor vasculature. Additionally, PCCAs can be vaporized into echogenic microbubbles for diagnostic ultrasound imaging. Previous studies have demonstrated that the vaporization threshold of PCCAs is higher in vivo than...
In vivo estimation of attenuation coefficients is useful because of its potential for tissue characterization and relevance in accurate backscatter coefficient estimation. However, current methods based on spectral analysis for ultrasonic attenuation estimation suffer from a severe trade-off between estimation precision and spatial resolution. Recently, the regularized spectral log difference (RSLD)...
Current liver cancer ablation methods are mainly thermal-based and inherently exhibit inconsistent tissue ablation due to irregular heat dissipation. Histotripsy is a non-thermal ultrasound (US) ablation method that fractionates tissue through the precise control of acoustic cavitation. This paper studies the feasibility and chronic effects of non-invasive histotripsy for liver cancer ablation in...
Direct access to the electrical activation in the heart is crucial for understanding and diagnosing cardiac activation diseases such as arrhythmias. We have recently presented a fully integrated Ultrafast Acoustoelectric Imaging (UAI) system based on the acoustoelectric effect1 i.e., the modulation of the electrical impedance of a tissue by an ultrasound wave, which uses plane wave emissions to provide...
Increased myocardial stiffness is characteristic of many diseases, leads to a loss of diastolic function, and is a cause of diastolic heart failure (DHF). Methods to estimate myocardial stiffness include Shear Wave Elastography (SWE). Currently, ultrasound-based cardiac SWE includes acoustic radiation force (ARF)-based methods; however, the in vivo generation and detection of the shear waves in myocardium...
The BRICHOS domain is encoded in more than 30 genes associated with cancer, dementia (BRI2/ITM2b) and amyloid lung disease (proSP-C). Studies have demonstrated that it delays fibril formation and toxicity of amyloid-β peptide (Aβ) in vitro and in vivo, which plays a central role in the development of Aβ amyloid plaques, one hallmark of Alzheimer's disease (AD). It has been shown that overexpression...
Angiogenic vasa vasorum (VV) is an important marker for atherosclerotic plaque progression and vulnerability. However, current in vivo imaging of tiny VV near a major vessel is limited. The super-resolution ultrasound imaging (SRI) can be a promising candidate. Microbubbles (MBs) localization technique for common SRI excludes signals from densely distributed MBs, requiring a large number of frames,...
Strain imaging is gaining traction as a means to assess cardiac function by tracking the cyclic deformation of the myocardium. Compared to traditional measures such as ejection fraction, global myocardial strain has been shown to be an earlier and more sensitive measure of overall ventricular function. Similarly, regional myocardial strain has been shown to be useful for identifying ischemia and myocardial...
A great need exists to non-invasively quantify the neurotransmitter activity in real-time to build a comprehensive functional map of a brain. In this paper, we present real-time recording of neuronal membrane potential change in vivo using transcranial photoacoustic (PA) voltage-sensitive dye (VSD) imaging on a rat in seizure.
Conventional 2D Doppler ultrasound is a valuable screening tool for early detection of cardiovascular disease, including aneurysm of the abdominal aorta (AA) and stenosis of the carotid artery (CA). However, vascular ultrasound screening rates remain low and vary widely among physicians, due to the need for a skilled sonographer, equipment costs and scan time. We have recently developed a low-cost...
There are two generally used ultrasonic approaches to extract sets of quantitative parameters: the Lizzi-Feleppa (LF) and quantitative ultrasound (QUS) approaches. The LF approach estimates LF parameters from the linear fit of the backscatter coefficient (BSC), and yields slope, intercept and midband. The QUS approach relies on the attenuation coefficient (AC) and BSC versus frequency, and yields...
While skeletal muscle is often assumed to be structurally transversely isotropic, its mechanical anisotropy is not well characterized in vivo. Such in vivo characterization can be achieved using VisR ultrasound, a technique that provides information about the viscoelastic mechanical response of tissue. Specifically, VisR-derived Relative Elasticity (RE) provides directionally dependent information...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.