Abstract. The effects of splenectomy in 41 patients managed from 1982 to 1995 at Sher-i-Kashmir Institute of Medical Sciences, Srinagar (Jammu and Kashmir), India, were studied. Immune thrombocytopenic purpura (ITP) was the main indication for therapeutic splenectomy among all the hematologic disorders. The mean age was 30 years (range 764), and the male to female ratio was 1.05:1. The mean platelet count in the preoperative period was 31,751/mm3 (range 400085,000). All patients presented with thrombocytopenia, i.e., platelet count of 100,000/mm3. In addition, 5 patients presented with anemia, i.e., Hb 10 g%. Among the patients with thrombocytopenia, 30 patients presented with counts 50,000/mm3 and 11 patients presented with counts between 50,000100,000/mm3. None of the patients presented with leukopenia. The morbidity observed was 15% and mortality was 2%. The response to splenectomy was complete for thrombocytopenia in 3 patients and partial in 5 patients; 4 patients failed to show any response. In anemic patients, 4 patients showed complete response and 1 patient showed no response. The prognosis was excellent in patients with platelet count 50,000/mm3, age 50 years, no concomitant disease, and disease of shorter duration.