Preliminary evidence exists through single case reports that psychophysiological interventions may be useful in the treatment of syncope (fainting). To explore this possibility, a case series of ten patients with histories of recurrent unexplained syncope or near syncope, headache, and a poor response to or tolerance for medication was performed. All patients were treated with electromyographic, thermal, biofeedback as well as progressive and autogenic relaxation. Six of the ten patients showed a major decrease in symptoms at the end of treatment. Descriptive comparisons between the improved and unimproved group were made and a detailed case study of one improved patient is presented. The results suggested that biofeedback-assisted relaxation treatment was most effective in younger patients whose syncope was associated with a strong psychophysiological response and whose headaches were intermittent, not daily occurrences.