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Background and Aims
Alcohol use disorder (AUD) is associated with increased risk of non‐fatal suicide attempt. We aimed to measure the strength and mechanistic nature of the association between AUD and increased suicide attempt and determine any causal pathways and/or shared risk factors.
Design
We used Cox proportional hazards models in population‐level and co‐relative analyses to evaluate the...
Background and aims
High‐risk alcohol consumption is associated with compromised health. This study aimed to compare the incidence of alcohol‐related cancers, diabetes, ischemic heart disease (IHD) and mortality between those with and without an indication of alcohol use disorder (AUD).
Design
Retrospective, population‐based, matched cohort study using data from the Manitoba Population Research...
Aim
To test the association of alcohol consumption with total and cause‐specific mortality risk.
Design
Prospective observational multi‐centre population‐based study.
Setting
Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project.
Participants
A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men).
Measurements
Average alcohol intake...
Aims
To estimate the risks of 12 types of somatic disease—alcohol‐related, blood, cancer, circulatory, digestive, endocrine and metabolic, genitourinary, infectious, musculoskeletal, nervous, respiratory and skin—in individuals with parental alcohol use disorder (AUD) versus a reference population, and to estimate the risks of all‐cause mortality and of death from an alcohol‐related cause.
Design...
Background and aims
Family history of substance use disorder (SUD) affects a child's risk of the disorder through both genetic and shared environmental factors. We aimed to estimate the association between parental or older sibling SUD history with the risk of adolescent SUD diagnosis.
Design, setting and participants
We conducted a population‐based cohort study using administrative health‐care...
Background and aims
Tolerance to the effects of alcohol is an important element in the diagnosis of alcohol use disorders (AUD); however, there is ongoing debate about its utility in the diagnosis AUD in adolescents and young adults. This study aimed to refine the assessment of tolerance in young adults by testing different definitions of tolerance and their associations with longitudinal AUD outcomes...
Background and Aims
Substance use disorder (SUD) is related to widespread adverse consequences, including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non‐fatal suicide attempt among individuals with SUD by focusing upon aggregate genetic risks and both childhood and past‐year environmental...
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