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Background and aims
Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed medications for patients with anxiety/depression. These patients often have problems with substance use, but it remains unclear whether the risk of substance misuse is influenced by SSRI treatment. We aimed to determine whether SSRI treatment is associated with a decreased risk of acute substance misuse‐related...
Background and Aims
The idea that cannabis is a ‘gateway drug’ to more harmful substances such as opioids is highly controversial, yet has substantially impacted policy, education and how we conceptualize substance use. Given a rise in access to cannabis products and opioid‐related harm, the current study aimed to conduct the first systematic review and meta‐analysis on the likelihood of transitioning...
Background and Aims
Initial use of drugs such as tobacco and alcohol may lead to subsequent more problematic drug use—the ‘gateway’ hypothesis. However, observed associations may be due to a shared underlying risk factor, such as trait impulsivity. We used bidirectional Mendelian randomization (MR) to test the gateway hypothesis.
Design
Our main method was inverse‐variance weighted (IVW) MR, with...
Background and Aims
This study aimed to (1) describe trends in stimulant‐alone and stimulant and other substance use overdose deaths from 2012 to 2018 and (2) measure patient and service use characteristics across stimulant‐related overdose death profiles.
Design
Retrospective cohort study of patients who died from stimulant‐involved overdose between annual years 2012 and 2018.
Setting
United...
Background and Aims
Molecular genetic studies of alcohol and nicotine use have identified many genome‐wide association study (GWAS) loci. We measured associations between drinking and smoking polygenic scores (PGS) and trajectories of alcohol and nicotine use outcomes from late childhood to early adulthood, substance‐specific versus broader‐liability PGS effects, and if PGS performance varied for...
Background and Aims
Lapse risk when trying to stop or reduce harmful substance use is idiosyncratic, dynamic and multi‐factorial. Just‐in‐time adaptive interventions (JITAIs) aim to deliver tailored support at moments of need or opportunity. We aimed to synthesize evidence on decision points, tailoring variables, intervention options, decision rules, study designs, user engagement and effectiveness...
Aims
To investigate whether e‐cigarette and cigarette susceptibility predict e‐cigarette and cigarette use among American youth 1 year later.
Design and Setting
Longitudinal data from the Population Assessment of Tobacco and Health (PATH) Study—a four‐stage, stratified probability cohort study of youth (12–17 years old) sampled from the United States civilian, non‐institutionalized population....
Background and aims
There are few longitudinal studies assessing the association of cannabis use and subsequent onset of bipolar disorder. We aimed to measure the association between early cannabis exposure and subsequent bipolar disorder.
Design, Setting and Participants
Observational study linking a sample from the northern Finland birth cohort 1986 (n = 6325) to nation‐wide register data to...
Background and Aims
A fast‐growing body of literature linking emotion dysregulation to substance use has almost exclusively relied on cross‐sectional designs and has generally failed to assess dysregulation stemming from positive emotions. The current study measured the momentary associations between both negative and positive emotion dysregulation and substance use, as well as the moderating role...
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