The similar material research method was adopted in this research to study the generation and migration law of dust in the process of discharge. The study result shows that the relation between the dust concentration and discharge rate in the unloading area is c = 6.622(Mpr)0.37348 for real conditions derived from similar materials experiment, which can be verified mutually with the numerical simulation result. When the natural air flow in real conditions increased to 1.89 m/s, the dust concentration reached the maximum value, and then, the dust diffusion rate accelerated and the dust concentration decreased. The smaller the ore particle size, the larger the area of interaction with the air, and the larger the dust concentration. An increase of the ore moisture content can reduce the dust concentration and keep the dust concentration at a low level. Additionally, the moisture content of the ore powder without hardening was 4.17–8%. As the height of the intermediate mine heap increased, the dust produced by both falling and impact decreased, and the dust concentration decreased. The dust removal effect of installing the seal cover was verified. The research results can provide a reference for dust control of an intermediate mine heap.