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Most disease association mapping algorithms are based on hypothesis testing procedures that test one variant at a time. Those methods lose power when the disease mutations are jointly tagged by multiple variants, or when gene‐gene interaction exist. Nearby variants are also correlated, for which procedures ignoring the dependence between variants will inevitably produce redundant results. With a large...
We have developed a computationally efficient method for multipoint linkage analysis on extended pedigrees for trait models having a two‐locus quantitative trait loci (QTL) effect. The method has been implemented in the program, hg_lod, which uses the Markov chain Monte Carlo (MCMC) method to sample realizations of descent patterns conditional on marker data, then calculates the trait likelihood for...
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