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With the development of sequencing technologies, the direct testing of rare variant associations has become possible. Many statistical methods for detecting associations between rare variants and complex diseases have recently been developed, most of which are population‐based methods for unrelated individuals. A limitation of population‐based methods is that spurious associations can occur when there...
DNA methylation is an important epigenetic mechanism that has been linked to complex diseases and is of great interest to researchers as a potential link between genome, environment, and disease. As the scale of DNA methylation association studies approaches that of genome‐wide association studies, issues such as population stratification will need to be addressed. It is well‐documented that failure...
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