Journal of Biomedical Materials Research Part B: Applied Biomaterials
Functional autologous tubular tissues, termed “biotubes,” have been developed as small‐caliber vascular grafts. Biotubes can be easily and safely constructed in vivo by using a novel concept in regenerative medicine—in body tissue architecture technology, which requires neither clean specialized laboratories nor complex cell management. Biotubes with “anastomotic reinforcement cuffs” were prepared...
In recent years, calcium phosphate cements (CPCs) have frequently been used as bone substitutes in the field of orthopedic surgery. When CPC is used as a bone substitute in vivo, blood contamination is unavoidable. To date, however, no detailed study has been conducted focusing on how the physical properties of CPCs would change under the influence of blood. In this study, the effects of blood contamination...
This study was performed to determine the in vitro biocompatibility of a bioactive, antibacterial silver based gel. A human osteoblast‐like cell line (HOS TE85) was used to test cytocompatibility in the presence of eluants and the biological response in direct contact with Na2O·CaO·2SiO2 gel (containing 0.5050 wt % Ag2O prepared by a sol–gel process) sterilized by two different methods; autoclave...
Polyethylene (PE) debris has been well studied in clinical retrievals and laboratory wear simulations of total hip replacements. However, little is known about PE debris from total knee replacements. In this study, we investigated the effects of crosslinking PE bearings and alternate counterface material. Mildly (35 kGy) and highly (70 kGy) crosslinked PE were studied in combination with CoCr and...
Resin adhesion to dentin was first achieved in 1982 through mechanical hybridization between resin and collagen fibrils using an adhesive resin containing a functional monomer. Over the last 2 decades, newly developed adhesive resins have attempted to improve the bond strength at least in the first 24 h after bonding. Although much is known about the initial bond strength, learned through morphological...
A novel nanohybrid hydrogel was in situ prepared by means of a free radical crosslinking polymerization route of methacrylic acid in the presence of multi‐walled carbon nanotubes (MWCNTs). The structural and morphological characterizations revealed that poly(methacrylic acid) networks (PMAA) closely covered the MWCNTs, and a MWCNT‐well‐dispersed nanohybrid hydrogel was formed. The addition of MWCNTs...
A nanotopographic noble metal (Ag, Au, Pd) coating has been applied on commercial urinary catheters and used in more than 80,000 patients, with good clinical results. We have previously evaluated the biocompatibility of different variations of this coating, showing high cellular viability and function in vitro. However, the reasons for good clinical and preclinical behavior are not known. This in vivo...
In this work, a biodegradable poly(ethylene glycol)‐poly(ε‐caprolactone)‐poly (ethylene glycol) (PEG‐PCL‐PEG, PECE) triblock copolymer was successfully synthesized, which was flowing sol at low temperature and turned to nonflowing gel at body temperature. The toxicity evaluation of PECE hydrogel as a potential in situ sustained opthalmic drug delivery system was performed, including the biodegradability...
The rapid developments and success in percutaneous vascular surgery over the last two decades with the now common stent grafts implantation, make the noninvasive surgery technique today attractive even for heart valve replacement. Less traumatic for the patient and also less time consuming, percutaneous heart valve replacement is however at its beginning and restricted to end of life patients. The...
Purpose: Modern metal‐on‐metal (MoM) joint articulations releases metal ions to the body. Research tries to establish how much this elevates metal ion levels and whether it causes adverse effects. The steel needle that samples the blood may introduce additional chromium to the sample thereby causing bias. This study aimed to test that theory. Methods: We compared serum chromium values for two sampling...
Malunion after a distal radius fracture can be treated with an osteotomy of the distal radius. Autologous iliac crest bone graft is often used to fill the gap, but the procedure is associated with donor site morbidity. In this study a novel fast resorbing biphasic bone substitute consisting of a mixture of calcium sulphate and calcium phosphate is used (Cerament™ BoneSupport AB, Sweden). Fifteen consecutive...
Injections of silicone fluid have been clinically evaluated to treat and prevent foot ulcers due to diminished plantar fat‐pad in neuropathic diabetics. The objective of this study was to determine preliminary in vitro effects of an injectable form of silicone resin particles in combination with growth factors to determine the suitability of this potential therapy for prevention of diabetic foot ulcers...
The purpose of this study was to analyze the sealing ability of various filling combinations in a 90 days period using fluid transport and glucose penetration models. Premolars (n = 108) were filled with either gutta‐percha (groups 1–4) or Resilon (groups 5–8) core materials combined with AH Plus (groups 1, 3, 5, 7) or Epiphany (groups 2, 4, 6, 8) sealers by using cold lateral compaction (groups 1,...
Polyesterpolyolacrylate/bentonite nanocomposites, capable of in situ photo polymerization, were synthesized and characterized. The organically modified bentonite clay was prepared by an ion exchange process, in which sodium ions were replaced by alkyl ammonium ions. Organo modification of bentonite was confirmed from X‐ray diffraction and fourier transform‐infrared data. Microstructures were characterized...
In this study, sodium clodronate, a well‐known therapeutic agent from the family of bisphosphonates (BPs), is incorporated in a biomimetic calcium phosphate (CaP) coating, previously formed on the surface of a starch‐based biomaterial by a sodium silicate methodology, as a strategy to develop a site‐specific drug delivery system for bone tissue regeneration applications. The effects on the resulting...
Glutaraldehyde crosslinked bioprosthetic heart valves (BHVs) have two modalities of failure: degeneration (cuspal tear due to matrix failure) and calcification. They can occur independently as well as one can lead to the other causing co‐existence. Calcific failure has been extensively studied before and several anti‐calcification treatments have been developed; however, little research is directed...
Fragmin (low‐molecular‐weight heparin)/protamine microparticles (F/P MPs) immobilize to culture plates, thereby retaining the binding of heparin‐binding cytokines such as human stem cell factor (SCF). The purpose of this study was to evaluate the ability of F/P MP‐coating to immobilize, stabilize, and enhance SCF‐activity. Cell assays showed that SCF and preimmobilized SCF on F/P MP‐coated plates...
It has been demonstrated that chlorhexidine digluconate (CHX) is capable of eliminating bacteria that may remain lodged in dentin after mechanical caries removal. In addition, the use of CHX on acid‐etched dentin before adhesive system application delays the resin–dentin interface degradation, maintaining the integrity of the adhesive restorations. Despite these advantages of using CHX in restorative...
A porous keratin scaffold, prepared from the reduced keratin solution, has shown good cell viability which makes it a potential candidate for cell seeding. An aqueous solution of reduced keratin was extracted from horn meal using a mixture of urea, sodium dodecyl sulfate, mercaptoethanol, and water at 60°C. The molecular mass of the extracted keratin is found to be ranging between 225 and 150 KDa...
Large segmental diaphyseal bone defects can be reconstructed with massive structural allografts, but this technique is associated with high complication rates. Tantalum tabecular metal implants have been successfully used to restore bone defects associated with revision total knee or hip arthroplasties. The aim of this study was to investigate if tantalum cylinders could be used to reconstruct large...