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A hetero‐bifunctional tetra(ethylene glycol) molecule with silane and azide termini was synthesized, and this molecule was used to prepare azide‐derivatized glass surface in one step. The resulting glass surface was available for fabricating peptide microarray by the conjugation with alkyne‐containing peptide using click chemistry, which proceeded to the completion at low temperature and in aqueous...
Macromolecules present a remarkable potential as future therapeutics. However, their translation into clinical practice has been hampered by an inherently low bioavailability. Cell‐penetrating peptides (CPP) have been recently shown to significantly improve on the bioavailability of macromolecules. Yet, the high cost associated with development and production of these peptides is a major factor hindering...
Pectins, complex plant‐derived polysaccharides, are novel candidates for biomaterial nanocoatings. Pectic rhamnogalacturonan‐I regions (RG‐I) can be enzymatically treated to so‐called modified hairy regions (MHR). We surveyed the growth and differentiation of murine preosteoblastic MC3T3‐E1 cells on Petri dishes coated with RG‐Is from native or genetically engineered potato tubers. Uncoated tissue...
We developed an ultra‐purified in situ forming gel as an injectable delivery vehicle of bone marrow stromal cells (BMSCs). Our objective was to assess reparative tissues treated with autologous BMSCs implanted using the injectable implantation system into osteochondral defects in a canine model. Forty‐eight osteochondral defects in the patella groove of the knee joint were created in 12 adult beagle...
The time‐dependent local drug delivery from drug‐eluting stents (DES) plays a critical role in reducing restenosis in intravascular stenting. To better understand the basic mechanism of drug release for certain polymer‐drug‐coated DES platforms, a cylindrical diffusion model was applied successfully to quantitatively describe the experimental drug release data of Dynalink‐E in vitro and in vivo. The...
In this study, a bioactive complex containing nonwoven textile material (polypropilene (PP)/viscose), chitosan hydrogel, and lidocaine hydrochloride, was designed. The purpose of such biomedical textile was in the treatment of painful sites. Mercury intrusion porosimetry was used in order to estimate the influence of medical impregnation on porous structure of nonwoven material. It was estimated that...
Model surfaces of polyurethane‐gold nanocomposites (PU‐Au) were used to examine cell behavior on nanophase‐segregated materials. Previously we showed that endothelial cell (EC) migration on these materials was modulated by the PI3K/Akt/eNOS pathway. The present study, investigated the expressions of alpha5/beta3 (α5β3) integrin, focal adhesion kinase (FAK), and other downstream signal molecules such...
Conformational changes of fibronectin (Fn) deposited on poly(methyl methacrylate) and poly(acrylic acid) block copolymers with identical chemical compositions were detected using an antibody‐functionalized atomic force microscope (AFM) tip. Based on the antibody‐protein adhesive force maps and phase imaging, it was found that the nanomorphology of the triblock copolymer is conducive to the exposure...
Often bladder dysfunction and diseases lead to therapeutic interventions that require partial or complete replacement of damaged tissue. For this reason, the development of biomaterials to repair the bladder by promoting the adhesion and growth of urothelial cells is of interest. With this aim, a modified copolyester of biocompatible and biodegradable poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) [P(HB‐...
We investigate the effect of bladder‐derived acellular matrix (ACM) on bone marrow mesenchymal stem cells (BM‐MSC) growth, survival, and differentiation, and evaluate the effect of collagen I and IV on BM‐MSC differentiation potential to SMC. BM‐MSCs isolated from CD1_mice were characterized by surface markers and differentiation into different lineages. BM‐MSC SMC potential was further evaluated...
To date, most interfacial tissue engineering approaches have used stratified designs, in which there are two or more discrete layers comprising the interface. Continuously graded interfacial designs, where there is no discrete transition from one tissue type to another, are gaining attention as an alternative to stratified designs. Given that osteochondral regeneration holds the potential to enhance...
Biomaterial nanotopographies have been proposed as a means to significantly influence cell functions (including osteoblasts, fibroblasts, endothelial cells, chondrocytes, immune cells, and bacteria). In this study, lung epithelial carcinoma cell functions including adhesion (up to 4 h), proliferation (up to 3 days), apoptosis (up to 5 days), and vascular endothelial growth factor (VEGF) synthesis...
Herein we report on a preparation and performance of stable, hydrophilic and biocompatible polymeric material suitable for functionalization of disposable substrates used in biosensors. This new material features COOH surface groups cross‐linked with ethylene glycol molecules and was prepared in situ on disposable, plastic substrate by high‐throughput and environmentally friendly technique called...
We generated parallel elastic fibers from synthetic elastin (SE) as a model of the arterial media and assessed the alignment of smooth muscle cells (SMCs). SE utilized crosslinked electrospun human tropoelastin to form aligned fibers that mimicked the topography and elastin‐rich content of the medial extracellular matrix. Bundled parallel fibers were anisotropically more elastic than randomly arranged...
Silk fibroin is a very promising biomedical material because of its renewability, nontoxicity, biocompatibility, and biodegradability. On the basis of a simple and mild method for the preparation of silk fibroin nanospheres with controllable size, the authors developed earlier, anti‐cancer drug paclitaxel (PTX)‐loaded silk fibroin nanospheres ranging from 270 to 520 nm were produced accordingly. The...
A fiber‐reinforced degradable scaffold for replacement of meniscal tissue was designed, fabricated, and mechanically evaluated. The hypotheses were that (1) the fiber network design would share a portion of compressive loads via the generation of circumferential tensile loads, and (2) the scaffold tensile properties would be similar to those of the meniscus. Two meniscus scaffold designs varying in...
A new “plug and play” polymeric template with the driving force of host–guest interaction between β‐CD and naphthalene‐modified functional groups was designed and studied. Multiple functional groups can be loaded into the template directly and conveniently. Importantly, the “plug and play” effect of the polymeric template is reversible and the functional groups could be removed from the polymeric...
Joint replacements should be firmly anchored in vital bone to avoid early implant subsidence and late aseptic loosening. We investigated whether the fixation of orthopedic implants could be improved by adding an osteoinductive extract of lyophilized equine bone matrix proteins (Colloss E, Ossacur AG, Germany), between the implant and the surrounding bone. Eighteen uncemented HA‐coated implants were...
Low‐molecular weight polyethylenimine (LMW PEI) shows the advantage of low‐cytotoxicity, but has been inefficient in gene delivery as a consequence of the low‐charge density. A number of previous studies employed the approach of crosslinking to solve this problem. In this study, a starburst LMW PEI gene vector has been developed. It has a polyamidoamine (PAMAM) core conjugated with a shell composed...
Herein, a novel Pluronic F127/graphene nanosheet (PF127/GN) hybrid was prepared via an one‐pot process including the simultaneous reduction of graphene oxide and assembly of PF127 and GN. The nanohybrid exhibits high water dispersibility and stability in physiological environment with the hydrophilic chains of PF127 extending to the solution while the hydrophobic segments anchoring at the surface...
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