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Background & Aims
Alagille syndrome (ALGS) manifests with peripheral intrahepatic bile duct (IHBD) paucity, which can spontaneously resolve. In a model for ALGS, Jag1Ndr/Ndr mice, this occurs with distinct architectural mechanisms in hilar and peripheral IHBDs. Here, we investigated region‐specific IHBD characteristics and addressed whether IGF1, a cholangiocyte mitogen that is downregulated...
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