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Objective
This study aimed to determine whether children and adolescents demonstrate, similarly to adults, a threshold of total percent body fat (%BF) above which the slope of visceral adipose tissue (VAT) rises.
Methods
This cross‐sectional study included 557 youth, aged 8 to 18 years, with a wide range of BMI values. Dual‐energy x‐ray absorptiometry was used to determine body composition (including...
The built environment (BE) has been viewed as an important determinant of health. Numerous studies have linked BE exposure, captured using a variety of methods, to diet quality and to area prevalence of obesity, diabetes, and cardiovascular disease. First‐generation studies defined the neighborhood BE as the area around the home. Second‐generation studies turned from home‐centric to person‐centric...
Objective
This study aimed to assess whether a counselor‐initiated (CI) adaptation of the Look AHEAD (Action for Health in Diabetes) intensive lifestyle intervention in a military setting was cost‐effective relative to a self‐paced (SP) adaptation.
Methods
A cost‐effectiveness analysis from a payer perspective was performed alongside a 2014‐2017 randomized behavioral weight loss trial among 248...
Objective
This study was undertaken to identify metabolites associated with BMI and waist circumference (WC) in women and to determine whether these metabolites are associated with biomarkers of metabolic health.
Methods
Untargeted metabolomic analysis was done on serum from 1,534 women. Metabolites associated with BMI and WC were identified using linear regression with a Bonferroni‐corrected P...
Objective
This study aimed to examine the relationship between proximity to healthy and unhealthy food outlets around children’s homes and their weight outcomes.
Methods
A total of 3,507,542 student‐year observations of height and weight data from the 2009‐2013 annual FitnessGram assessment of New York City public school students were used. BMI z scores were calculated, student obesity or obesity/overweight...
Objective
This study aimed to identify the association between the food environment and obesity.
Methods
BMI and waist circumference (WC) were measured in 8,076 participants from three cities. The number of fast‐food restaurants, full‐service restaurants, bars/pubs, markets, and liquor stores within 500 m of each participant was documented. The association between the food environment (ratio of...
Objective
This study aimed to understand how an increase in abdominal adiposity relative to overall adiposity is associated with blood pressure (BP) change.
Methods
A sex‐stratified mixed linear model was used to examine the association (95% CI) between annual changes in waist circumference (WC) and systolic blood pressure and diastolic blood pressure, estimated from two to eight repeated measures...
Objective
This study aimed to explore the individual and combined effects of skim milk powder (SMP) and exercise on indices of systemic and liver lipid metabolism in male obese rats.
Methods
Rats were fed a high‐fat (~ 40% kcal from fat), high‐sugar diet for 8 weeks. At 12 weeks of age, rats were assigned to one of four weight‐matched, isocaloric, high‐fat, high‐sugar groups for 6 weeks: (1) casein‐sedentary,...
Objective
Improving neighborhood walkability has been proposed as a policy intervention to reduce obesity. The objective of this study was to evaluate longitudinal relationships between neighborhood walkability and body weight among adults living in large urban areas.
Methods
In this retrospective longitudinal study of United States military veterans using Department of Veterans Affairs health...
Objective
Clinical relevance of global DNA methylation and one‐carbon metabolite levels with histological severity remains uncertain in patients with nonalcoholic fatty liver disease (NAFLD). This study aimed to evaluate hepatic global DNA methylation and serum one‐carbon metabolite concentrations in patients with NAFLD and the possible associations of these parameters with liver histology.
Methods...
Objective
This study investigated how changes in 84 proteins over a 10‐year period of aging were related to changes in measures of body fat and distribution over the same period.
Methods
Cardiovascular candidate proteins were measured using the proximal extension assay technique, along with BMI and waist‐hip ratio (WHR), at ages 70, 75, and 80 in 1,016 participants of the Prospective Investigation...
Objective
Abnormal liver function tests in children and young people (CYP) predict a greater burden of liver disease in adulthood, especially in the context of obesity. This study aimed to determine whether obesity and metabolic risk factors predict liver function testing and abnormal liver test results in CYP.
Methods
This was a retrospective cross‐sectional population study using electronic health...
Objective
The use of relative and absolute effect estimates has important implications for the interpretation of study findings. Likewise, examining additive and multiplicative interaction can lead to differing conclusions about the joint effects of two exposure variables. The aim of this paper is to examine the relationship between BMI and mortality on the relative and absolute scales and investigate...
Objective
Women with metabolic syndrome (MetS) have higher endogenous testosterone (T) levels than unaffected women. This study investigated whether hyperandrogenemia (HA) was a marker for increased cardiometabolic risk in reproductively normal premenopausal women.
Methods
Reproductive hormones and metabolic parameters were assessed in 198 women with regular menses and no clinical hyperandrogenism...
Objective
This study aimed to investigate the effects of liraglutide on the body weight set point (BWSP) in diet‐induced obese rats and to determine the relationship between BWSP and hypothalamic arcuate nucleus (ARC) microglial activation.
Methods
Diet‐induced obesity (DIO) rats were divided into three groups: continuous high‐fat diet (HFD) plus saline, HFD with liraglutide, and HFD with liraglutide...
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