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The steady rise in the prevalence of obesity has had a negative impact for people living with obesity. This includes health care and social disparities that lead to diminished quality of life and social prosperity. Even though discrimination based on weight has a negative impact on people’s health and wellness, there is only one state in the United States, Michigan, that has an antiweight discrimination...
Objective
Restricting dietary methionine to 0.17% in mice increases energy expenditure (EE), reduces fat deposition, and improves metabolic health by increasing hepatic fibroblast growth factor 21 (FGF21). The goal of this study was to compare each of these responses in mice with the coreceptor for FGF21 deleted in either adipose tissue or the brain.
Methods
Methionine‐restriction (MR) diets were...
Objective
This study aims to explore the indicators for severity of coronavirus disease 2019 (COVID‐19) in young patients between the ages of 18 and 40 years.
Methods
This retrospective cohort study included 65 consecutively admitted patients with COVID‐19 who were between 18 and 40 years old in Zhongnan Hospital of Wuhan University in Wuhan, China. Among them, 53 were moderate cases, and 12 were...
Objective
An important notion in personalized medicine is that there is clinically relevant treatment response heterogeneity. Low‐carbohydrate (CHO) and low‐fat diets are widely adopted to reduce body mass. To compare individual differences in responses between two dietary interventions, a formal statistical comparison of response variances between study arms in a randomized controlled trial (RCT)...
Objective
This study aimed to estimate the associations of gestational weight gain rate (GWGR) during different trimesters with offspring growth and overweight/obesity risk.
Methods
The study included 4,807 mother‐infant pairs enrolled in Wuhan, China. GWGR in each trimester was used as a continuous and a categorical variable to estimate the associations with offspring BMI z score (ZBMI) and overweight/obesity...
Objective
This study aimed to elucidate the mechanism by which hypertrophic adipocytes regulate insulin signaling in cardiac myocytes.
Methods
Palmitate was used to induce hypertrophic 3T3‐L1 adipocytes. Exosomes were purified from normal control or hypertrophic 3T3‐L1 adipocyte‐associated conditioned medium. Exosome‐exposed neonatal rat ventricular myocytes were stimulated with insulin to investigate...
Objective
Psychopathology in bariatric surgery patients may contribute to adverse postoperative sequelae, including weight regain, substance use, and self‐harm. This cross‐sectional study aimed to advance the understanding of the risk and protective paths through which weight bias associates with depressive and anxiety symptoms in bariatric surgery candidates (BSC).
Methods
BSC recruited from a...
Objective
The purpose of this study was to test the extent to which pregnancy per‐ and polyfluoroalkyl substance (PFAS) concentrations were associated with gestational weight gain and postpartum weight changes.
Methods
This study was composed of 1,614 women recruited between 1999 and 2002 via the Project Viva cohort with pregnancy plasma concentrations of six PFAS, including perfluorooctanesulfonic...
Background
Adherence to weight‐loss medication is suboptimal, leading to poor health outcomes. Short message service (SMS) can potentially improve adherence.
Methods
A total of 3,994 participants with overweight or obesity in Australia receiving Saxenda® (liraglutide 3.0 mg) were enrolled from September 1, 2017, to February 28, 2018, through doctors, pharmacists, or websites and were randomly assigned...
Objective
The aim of this study was to test whether increased energy expenditure (EE), independent of physical activity, reduces acute diet‐induced weight gain through tighter coupling of energy intake to energy demand and enhanced metabolic adaptations.
Methods
Indirect calorimetry and quantitative magnetic resonance imaging were used to assess energy metabolism and body composition during 7‐day...
Objective
This study sought to investigate how glycemia and ketonemia variations during two ketogenic diet protocols affect appetite, executive functions, and mood in young women with overweight.
Methods
Fifty healthy young females with overweight were randomly assigned to (1) a ketogenic diet without any restriction on energy intake, (2) a commercial energy‐restricted ketogenic Mediterranean diet,...
Objective
Obesity is influenced by genetic and environmental factors. Despite the success of human genome‐wide association studies, the specific genes that confer obesity remain largely unknown. The objective of this study was to use outbred rats to identify the genetic loci underlying obesity and related morphometric and metabolic traits.
Methods
This study measured obesity‐relevant traits, including...
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