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Objective
This study tested the hypothesis that treatment with the glucagon‐like peptide‐1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation).
Methods
This Phase 1b, double‐blind, randomized, placebo‐controlled study was conducted at two centers in inpatient...
Objective
This study examined the association between individual‐ and neighborhood‐level sociodemographic factors and surgical weight loss at 1 year (short term) and 3 years (long term).
Methods
Data were obtained from the baseline survey of the BELONG (Bariatric Experience Long Term) prospective longitudinal cohort study. Individual‐level self‐reported data on sex, race and ethnicity, education,...
Objective
A large, and potentially growing, disparity in obesity prevalence exists between large central metros and less urban United States counties. This study examines its key predictors.
Methods
Using a rich county‐year data set spanning 2006 to 2016, the authors conducted a Gelbach decomposition to examine the relative importance of demographic, socioeconomic, environmental, and behavioral...
Objective
The nucleus accumbens (NAc) plays critical roles in eating and food seeking in rodents and humans. Diets high in fats and sugars (“junk food”) produce persistent increases in NAc function in male obesity‐prone rats. This study examines effects of junk food and junk food deprivation on NAc core medium spiny neuron (MSN) excitability and glutamate transmission in females.
Methods
Obesity‐prone...
Objective
This study aimed to determine the independent effects of obesity and dynapenia on falls risk, areal bone mineral density, and fracture risk (lower extremity or all other fractures).
Methods
A total of 16,147 women (aged 60‐82 years) from the UK Biobank were categorized by handgrip strength (HGS; dynapenia status: HGS ≤ 21 kg) and body weight (BMI: normal weight, overweight, or obesity)...
Objective
This study aimed to examine whether baseline gray matter (GM) volume and structural covariance patterns could predict body fat gain over 1 to 2 years in a relatively large sample.
Methods
Voxel‐based morphometry (VBM) analysis was applied to examine the association between baseline GM volume and body fat gain in 502 participants over 1 to 2 years. Furthermore, this study tested whether...
Objective
Weight loss achieved with standard doses of glucagon‐like peptide‐1 (GLP‐1) agonists among real‐world patients with type 2 diabetes has not been determined. This study sought to describe the percent change in body weight 72 weeks after starting a GLP‐1 agonist.
Methods
A retrospective cohort study of nonpregnant adults who were first dispensed a GLP‐1 agonist between 2011 and 2018 was...
Objective
This study examined associations among perceived neighborhood walkability, physical activity (PA), and obesity among United States adults.
Methods
Data from the 2020 National Health Interview Survey were analyzed. Walkability was assessed using a summative scale and was categorized as low, medium, or high. PA was categorized as insufficient (0‐149 min/wk) or sufficient (150+ min/wk)....
Objective
Colchicine is known to reduce inflammation and improve endothelial cell function and atherosclerosis in obesity, but there is little knowledge of the specific circulating leukocyte populations that are modulated by colchicine.
Methods
A secondary analysis of a double‐blind randomized controlled trial of colchicine 0.6 mg or placebo twice daily for 3 months on circulating leukocyte populations...
Objective
Loss‐of‐control (LOC) eating is common in adults undergoing bariatric surgery. Agreement between real‐time and retrospective assessment methods is unclear.
Methods
Adults with severe obesity reported on LOC eating over the preceding 28 days via Eating Disorder Examination‐Questionnaire (EDE‐Q) items and in near real time over 10 days via ecological momentary assessment (EMA; involving...
Obesity is a growing public health crisis in the United States and is associated with a substantial disease burden due to an increased risk for multiple complications, including cardiovascular and metabolic diseases. As highlighted in this review, obesity disproportionately affects the African American population, women in particular, regardless of socioeconomic status. Structural racism remains a...
Objective
This study examined baseline predictors of rapid response and its prognostic significance in a clinical trial of behaviorally based weight loss treatment (BBWLT) for binge eating disorder in patients with obesity.
Methods
One hundred ninety‐one participants receiving BBWLT were assessed at baseline, throughout treatment, and at posttreatment (6 months) by independent assessors. Rapid...
Objective
The aim of this study was to compare changes in gastrointestinal hormones and appetite ratings after a similar weight loss induced by a very low‐energy diet alone or in combination with sleeve gastrectomy (SG) or Roux‐en‐Y gastric bypass (RYGB).
Methods
Patients with severe obesity scheduled for SG (n = 15) and RYGB (n = 14) and 15 controls (very low‐energy diet alone) were recruited...
Objective
Body mass index (BMI) does not directly measure adiposity, whereas dual‐energy x‐ray absorptiometry (DXA) provides valid direct estimates of adiposity. Therefore, this study evaluated usefulness of BMI as a measure of adiposity in serum metabolomics studies.
Methods
A cross‐sectional analysis was conducted of 202 women aged 25 to 29 years in the Dietary Intervention Study in Children...
Objective
In this study, the associations between the substitution of sedentary time with sleep or physical activity at different intensities and subsequent weight‐loss maintenance were examined.
Methods
This prospective study included 1152 adults from the NoHoW trial who had achieved a successful weight loss of ≥5% during the 12 months prior to baseline and had BMI ≥25 kg/m2 before losing weight...
Objective
In contrast to what is seen clinically, male mice are resistant to antipsychotic‐induced obesity. This is problematic as preclinical studies examining mechanisms of antipsychotic‐induced metabolic dysfunction might be relevant to only half the population. This study sought to determine whether housing mice at thermoneutrality and under conditions of preexisting obesity, steps that have...
Objective
This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12‐month behavioral weight‐loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers.
Methods
Participants (N = 374) were randomized to either diet alone (DIET), diet plus 150 min/wk of prescribed moderate‐intensity physical activity...
Objective
The incidence of women entering into pregnancy with BMI indicating overweight or obesity is rising with concurrent increases in adverse complications such as gestational diabetes. Although several studies have examined the compositional changes to the microbiome across BMI classifications, there has been no investigation regarding changes in microbial function during pregnancy.
Methods...
Objective
This retrospective study incorporated long‐term mortality results after different bariatric surgery procedures and for multiple age at surgery groups.
Methods
Participants with bariatric surgery (surgery) and without (non‐surgery) were matched (1:1) for age, sex, BMI, and surgery date with a driver license application/renewal date. Mortality rates were compared by Cox regression, stratified...
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