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Objective
Recent changes to the Chronic Kidney Disease Epidemiology Collaboration estimated glomerular filtration rate (eGFR) formula (2021 CKD‐EPI) removed race from the 2009 formula, increasing the number of Black people classified as having CKD, but these changes may impact eligibility and/or dosing for antiobesity medications. This study estimated the number of people with obesity nationwide...
Objective
This study explored the relationship between BMI and regional cerebral glucose metabolism and explicitly detected regions with significant differences in cerebral metabolism using positron emission tomography (PET)/magnetic resonance imaging in the resting state.
Methods
Corresponding PET images acquired from 220 participants were sorted into four groups according to Asian BMI standards:...
Objective
Bariatric surgeries involve manipulation of the viscera and are associated with significant postoperative pain. Paracetamol is a nonopioid analgesic with a rapid onset, and it is effective and safe. The study compared the effects of pre‐ and postincisional intravenous paracetamol administration for optimal postoperative pain management in patients undergoing bariatric surgeries.
Methods...
Objective
This study aimed to assess the association between changes in metabolic phenotypes and incident type 2 diabetes.
Methods
This retrospective cohort study included participants from a medical health checkup program conducted by the Panasonic Corporation, Japan, between 2008 and 2018. The metabolic phenotypes of the participants in 2008 and 2013 were assessed. The association between changes...
Objective
This study examined the association of weight loss following bariatric surgery with self‐reported sleep quality after accounting for other sleep‐related factors.
Methods
Participants were from the Bariatric Experience Long Term (BELONG) study. Participants completed a survey up to 6 months before surgery and approximately 1 year after surgery. The Pittsburgh Sleep Quality Index (PSQI)...
Objective
This study aimed to evaluate the multidisciplinary care model of the Canberra Obesity Management Service (COMS) with regard to patient demographics and clinical outcomes, particularly in comparison with previous COMS outcome reviews.
Methods
A retrospective chart review was carried out on all patients attending an initial assessment at COMS between July 2018 and June 2019. Existing patients...
Objective
This study assessed the cross‐sectional associations of low‐carbohydrate diets (LCDs) and low‐fat diets (LFDs) with hepatic steatosis in the National Health and Nutrition Examination Survey.
Methods
Diet was measured using the 24‐hour recalls. Hepatic steatosis was defined by vibration‐controlled transient elastography. The odds ratios (OR) and 95% confidence intervals (CI) were estimated...
Objective
It remains elusive whether prediagnostic BMI trajectory is associated with pancreatic cancer.
Methods
This study investigated this question among 145,489 participants who gave rise to 696 incident cases of pancreatic cancer over a median follow‐up of 12 years in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. At baseline, participants were asked to recall their...
Objective
Elevation of energy expenditure through an increase of brown adipose tissue (BAT) thermogenesis is regarded as one of the most promising ways to prevent obesity development. The preoptic area (POA) of the hypothalamus is a critical area for control of BAT thermogenesis. However, the intracellular signaling cascades in the POA for regulation of BAT thermogenesis are poorly understood.
...
Objective
The mechanisms linking obesity to type 2 diabetes (T2D) are not fully understood. This study aimed to identify obesity‐related metabolomic signatures (MESs) and evaluated their relationships with incident T2D.
Methods
In a nested case‐control study of 2076 Chinese adults, 140 plasma metabolites were measured at baseline, linear regression was applied with the least absolute shrinkage...
Objective
This study aimed to conduct an economic evaluation of the Communicating Healthy Beginnings Advice by Telephone (CHAT) trial to prevent childhood obesity.
Methods
Cost‐effectiveness analyses were conducted for the telephone and short message service (SMS) delivery of Healthy Beginnings advice, compared with usual care, which included child health services unrelated to Healthy Beginnings...
Objective
This study aimed to demonstrate noninferiority using telehealth in treating obesity with phentermine in patients with BMI ≥ 27 kg/m2 with comorbidities or BMI ≥ 30 compared with the standard in‐person approach over a 90‐day period.
Methods
A 12‐week, randomized, prospective, single‐center, open label trial compared the use of virtual visits versus in‐person visits for the treatment of...
Objective
The efficacy of services for children and adolescents with obesity is well researched, but this review describes what actually matters to stakeholders (children, caregivers, and professionals) in relation to such services.
Methods
A mega‐ethnography, an innovative review‐of‐reviews approach that uses conceptual findings as primary data, was performed. Twelve bibliographic databases (2010–2020)...
Objective
The aim of this study was to evaluate the effect of a novel, oral, modified‐release formulation of the lipase inhibitor orlistat and the glucosidase/amylase inhibitor acarbose (denoted EMP16) on relative body weight after 26 weeks compared with placebo.
Methods
The randomized, double‐blind, placebo‐controlled trial had a 26‐week treatment period, with dose escalation up to 6 weeks. Participants,...
Objective
This study aimed to assess the incremental cost‐effectiveness ratio (ICER) of a 2‐year motivational interviewing (MI) intervention versus usual primary care.
Methods
A national trial was implemented in the Pediatric Research in Office Settings (PROS) network of the American Academy of Pediatrics to evaluate MI versus usual care for children (2‐8 years old; baseline BMI 85th‐97th percentiles)...
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