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Objective
The goal of this study was to investigate laparoscopic sleeve gastrectomy (LSG)‐induced changes in choice impulsivity and the neural correlates in individuals with obesity (OB).
Methods
The study employed functional magnetic resonance imaging with a delay discounting task in 29 OB tested before and 1 month after LSG. Thirty participants with normal weight matched to OB with gender and...
Objective
The goal of this study was to compare measures of weight regain (WR) and their association with the glucose metabolism deterioration within 3 years following bariatric surgery among Chinese patients with obesity and type 2 diabetes mellitus (T2DM).
Methods
Among a retrospective cohort of 249 patients with obesity and T2DM who underwent bariatric surgery and were followed up to 3 years,...
Objective
The aim of this study was to evaluate the efficacy and safety of modified fasting therapy, and a retrospective study was conducted to analyze changes in clinical indicators of hospitalized fasting patients.
Methods
A total of 2054 hospitalized fasting patients were enrolled in this observational study. All participants underwent 7 days of modified fasting therapy. The clinical efficacy...
Chronic diseases of aging are increasingly common. Dementia, often due to multiple etiologies including Alzheimer disease (AD), is at the forefront. Previous studies have reported higher rates of dementia among persons with diabetes, yet less is known about how insulin resistance relates to cognition. This article reviews recently published data on the relationship of insulin resistance to cognition...
Objective
This study aimed to investigate whether a glucose‐dependent insulinotropic polypeptide (GIP) monoclonal antibody (mAb) will promote weight loss in wild‐type mice and to determine effects of this mAb in preventing weight gain in ob/ob mice.
Methods
Phosphate‐buffered saline (PBS) or GIP mAb was injected intraperitoneally to wild‐type mice fed a 60% high‐fat diet (HFD). After 12 weeks,...
Objective
Weight loss is one of the most common New Year's resolutions, but it is unclear whether attempting to lose weight in January is more successful than attempting it at other times of the year.
Methods
In this prospective cohort study from the English National Health Service (NHS) Diabetes Prevention Program, adults with nondiabetic hyperglycemia were enrolled in a structured behavioral...
Objective
Prader‐Willi syndrome (PWS) is a multisystem genetic disorder. Unfortunately, none of several mouse models carrying PWS mutations emulates the entirety of the human PWS phenotype, including hyperphagia plus obesity.
Methods
To determine whether housing at thermoneutrality (TN, 30 °C) permits the development of hyperphagia and obesity in the Snord116del PWS mouse model, the effects of...
Objective
The Mediterranean diet is associated with lower risks for type 2 diabetes (T2D) and cardiovascular disease in certain populations, although data among diverse groups are limited. This study evaluated cross‐sectional and prospective associations between a novel South Asian Mediterranean‐style (SAM) diet and cardiometabolic risk among US South Asian individuals.
Methods
The study included...
Objective
The aim of this study was to determine the effect of age of obesity onset on senescence‐related markers in abdominal (AB) and femoral (FEM) subcutaneous adipose tissue (SAT) before and after moderate (~10%) weight loss.
Methods
AB and FEM SAT were collected from human females with childhood‐onset obesity (CO) or adult‐onset obesity (AO) before and after diet‐ and exercise‐induced weight...
Objective
Family‐based weight stigma can be expressed as criticism, judgment, teasing, and mistreatment by family members because of an individual's body weight. The current study compared the prevalence and psychosocial correlates of family‐based weight stigma among adult members of a weight‐management program living in Australia, Canada, France, Germany, the UK, and the US.
Methods
Participants...
Objective
Higher doses of the glucagon‐like peptide‐1 agonists liraglutide and, more recently, semaglutide have demonstrated a significant reduction in body weight. However, their comparative value for money for this indication is unclear.
Methods
The cost needed to treat to achieve a 1% reduction in body weight using semaglutide or liraglutide was calculated. The body weight reductions were extracted...
Objective
No prior studies have evaluated inhibitory control in people with severe class III compared with class I/II obesity. Thus, the study aim was to evaluate inhibitory control and neural correlates of response inhibition by obesity class using a sample of endometrial cancer (EC) survivors with obesity, who have a higher risk of overall but not cancer‐specific mortality.
Methods
Forty‐eight...
Objective
The purpose of this study was to test the hypothesis that perfluorinated alkylate substance (PFAS) exposures are associated with body weight increases in a dietary intervention study.
Methods
In the DioGenes trial, adults with obesity first lost at least 8% of their body weight and then completed at least 26 weeks on a specific diet. Concentrations of five major PFASs were assessed in...
Objective
This systematic scoping review aimed to map and synthesize research on feasibility of time‐restricted eating (TRE) in individuals with overweight, obesity, prediabetes, or type 2 diabetes, including recruitment rate, retention rate, safety, adherence, and participants' attitudes, experiences, and perspectives.
Methods
The authors searched MEDLINE, Embase, and Cumulative Index to Nursing...
Objective
Cardiovascular health (CVH) declines in young adulthood. This study assessed whether weight gain prevention interventions promoted ideal CVH.
Methods
Young adults (n = 599; age 18–35 years; BMI: 21.0–30.9 kg/m2) from a randomized controlled trial comparing two weight gain prevention interventions (self‐regulation with large or small changes) and a self‐guided control group completed anthropometric...
Objective
As there is a lack of studies on adolescents and young adults with obesity, the Swedish Youth with Obesity cohort was set up to describe the long‐term results of medical, as well as surgical, obesity interventions in youth. This article describes the study protocol.
Methods
Since 2018, the study has continuously recruited patients aged between 16 and 25 years who have been admitted for...
Objective
The aim of this study was to quantify abdominal adiposity and generate data‐driven adiposity subtypes with different diabetes risks.
Methods
A total of 3817 participants from the Pinggu Metabolic Disease Study were recruited. A deep‐learning‐based recognition model on abdominal computed tomography (CT) images (A‐CT model) was developed and validated in 100 randomly selected cases. The...
Objective
Sympathetic nervous system overactivation and abnormal lipid metabolism are featured in obesity and may lead to cardiac remodeling. The effects of carotid baroreceptor stimulation (CBS) on cardiac remodeling in obese rats and the underlying mechanisms were explored.
Methods
An obesity model was induced by 16‐week high‐fat diet feeding. A CBS device was implanted at the 8th week. Body...
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