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Breast cancer is the most common and second deadliest malignancy in women. With rising obesity rates and building evidence for a strong association with obesity, the incidence of breast cancer can be expected to increase. Weight loss reduces breast cancer risk, the mechanisms of which are still poorly understood. As an effective therapy for obesity, bariatric surgery may be a powerful tool in breast...
Objective
Previously reported data regarding growth parameters in individuals with fragile X syndrome (FXS) are inconsistent. A longitudinal analysis of height and BMI in a large number of individuals with FXS was conducted.
Methods
Age‐ and sex‐specific z scores for height and BMI of 1,223 individuals with FXS were calculated based on published normative data. Mixed‐effect linear regression models...
Objective
A mother–child dyad trajectory model of weight and body composition spanning from conception to adolescence was developed to understand how early life exposures shape childhood body composition.
Methods
African American (49.3%) and Dominican (50.7%) pregnant mothers (n = 337) were enrolled during pregnancy, and their children (47.5% female) were followed from ages 5 to 14. Gestational...
Objective
This study tested the efficacy of a lower‐burden, simplified dietary self‐monitoring approach compared with a standard calorie monitoring approach for self‐monitoring adherence and weight loss in a mobile‐delivered behavioral weight loss intervention.
Methods
Participants (n = 72) with overweight or obesity who had children 2 to 12 years of age living in the home were randomly assigned...
Objective
Associations of obesity with cardiovascular disease may originate in childhood. This study examined critical periods for BMI in relation to arterial health at school age.
Methods
Among 4,731 children from a prospective cohort study, associations of infant peak weight velocity, both age and BMI at adiposity peak, and BMI trajectories with carotid artery intima‐media thickness and carotid...
Objective
This study investigated the effects of constant light exposure on polycystic ovary syndrome (PCOS)‐like endocrine and metabolic changes in high‐fat diet (HFD)‐fed rats and to elucidate the related microbiotic mechanisms.
Methods
A total of 32 female Sprague‐Dawley rats were divided into four groups (n = 8 each): rats on a normal chow diet with standard light‐dark cycle, rats on a normal...
Objective
Receptor‐interacting serine/threonine‐protein kinase 1 (RIP1) is a well‐documented key regulator of TNFα‐mediated inflammation, apoptosis, and necroptosis, which contribute to the development of obesity‐related metabolic diseases such as nonalcoholic steatohepatitis. However, the mechanism regarding how RIP1 influences obesity‐related insulin resistance remains elusive.
Methods
Primary...
Objective
The aim of this study was to explore the association of lifelong smoking status with risk of major adverse cardiovascular events (MACE) accounting for weight change in a Chinese cohort.
Methods
The cohort of the People’s Republic of China‐United States of America (PRC‐USA) Collaborative Study of Cardiovascular and Cardiopulmonary Epidemiology was established in 1983 to 1984, resurveyed...
Objective
The authors hypothesize that an untargeted metabolomics study will identify novel mechanisms underlying smoking‐associated weight loss.
Methods
This study performed cross‐sectional analyses among 1,252 participants in the Bogalusa Heart Study and assessed 1,202 plasma metabolites for mediation effects on smoking‐BMI associations. Significant metabolites were tested for associations with...
Objective
This study aimed to examine the association of socioeconomic status with obesity.
Methods
A total of 39,262 twin individuals were included from the Chinese National Twin Registry (CNTR). Generalized estimating equation models for unmatched twin individual analyses and conditional logistic regression for the co‐twin matched design were used. Inference about Causation through Examination...
Objective
Modest weight loss (5%‐10%) is clinically meaningful in patients with overweight or obesity. However, greater weight loss may be required to achieve improvements in or remission of certain weight‐related complications. Therefore, this study reviewed the effect of large weight loss (≥10%). Most studies reporting large weight loss and relevant outcomes used bariatric surgery or lifestyle...
Objective
In this study, the effect of lomitapide, a microsomal triglyceride transfer protein inhibitor, on the cardiovascular function in obesity was investigated.
Methods
Eight‐week‐old C57BL/6 mice were fed with high‐fat diet for 12 weeks in the presence and absence of lomitapide. Lomitapide was administered by gavage (1 mg/kg/d) during the last 2 weeks of high‐fat feeding. Body weight, blood...
Objective
The aim of this study was to determine whether the hormone changes following weight loss are proportional to the degree of weight loss and to starting BMI.
Methods
A very low‐energy diet was used to achieve 15% weight loss. Fasting and postprandial gut hormones and leptin were measured during a meal test at baseline and at 5% (1%), 10% (2%), and 15% (2.5%) weight loss. Linear mixed‐effects...
Objective
This study evaluated whether the transition of a face‐to‐face behavioral intervention to videoconferencing‐based telehealth delivery during the COVID‐19 pandemic resulted in significantly smaller weight losses than those typically observed in gold‐standard, face‐to‐face programs.
Methods
Participants were 160 adults with obesity (mean [SD] age = 49.2 [11.9] years, BMI = 36.1 [4.2] kg/m...
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