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Objective
Existing screening tools are inadequate in differentiating binge eating from normative overeating in treatment‐seeking individuals with overweight or obesity, as these individuals tend to overendorse loss‐of‐control (LOC; the hallmark characteristic of binge eating) on self‐report measures. In order for treatment centers to efficiently and accurately identify individuals who would benefit...
Objective
Experiments with animals suggest that high sugar consumption during pregnancy may predispose offspring to obesity, but few human studies have examined this relationship. This study explored the association between the consumption of sugar‐sweetened beverages (SSBs) during pregnancy and caloric intake through childhood.
Methods
Using cohort data on child weight, height, and physical activity...
Objective
In an ongoing effort to identify the genetic variation that contributes to obesity in American Indians, known Bardet–Biedl syndrome (BBS) genes were analyzed for an effect on BMI and leptin signaling.
Methods
Potentially deleterious variants (Combined Annotation Dependent Depletion score > 20) in BBS genes were identified in whole‐exome sequence data from 6,851 American Indians informative...
Objective
Loss‐of‐control (LOC) eating postoperatively is a consistent predictor of suboptimal longer‐term bariatric surgery outcomes. This randomized controlled trial examined the effectiveness of two guided self‐help treatments (cognitive behavioral therapy [gshCBT] and behavioral weight loss [gshBWL]) compared with a control (CON) for reducing LOC eating and weight.
Methods
A total of 140 patients...
Objectives
Self‐monitoring is critical for weight management, but little is known about lapses in the use of digital self‐monitoring. The objectives of this study were to examine whether lapses in self‐weighing and wearing activity trackers are associated with weight and activity outcomes and to identify objective predictors of lapses.
Methods
Participants (N = 160, BMI = 25.5 ± 3.3 kg/m2, 33.1...
Objective
This study examines BMI–mortality associations and evaluates strategies intended to limit reverse causality. Heterogeneity in BMI–mortality risk associations across subgroups and causes of death is explored.
Methods
A cohort of 654,382 adults from the US National Health Interview Survey was constructed. Associations between unit BMI levels and mortality were estimated using Cox proportional...
Objective
This study investigates the therapeutic potential of a small molecule inhibitor of plasminogen activator inhibitor‐1 (PAI‐1), TM5441, in reversing diet‐induced obesity in mice.
Methods
Wild‐type C57BL/6J mice were fed a high‐fat high‐sugar (HFHS) diet for 8 weeks to induce obesity. After the first 8 weeks, TM5441 was added to the diet for an additional 8 weeks. In order to determine the...
Objective
After Roux‐en‐Y gastric bypass (RYGB), postprandial hyperinsulinemic hypoglycemia (PPHH) is particularly critical because of the risk of trauma. The aim of this study was to assess the incidence and identify risk factors for symptomatic PPHH.
Methods
Patients with RYGB were classified into moderate PPHH (MH) or severe hypoglycemia (SH), which is defined as patients with neuroglycopenic...
Objective
Recent cohort studies have identified obesity as a risk factor for poor outcomes in coronavirus disease 2019 (COVID‐19). To further explore the relationship between obesity and critical illness in COVID‐19, the association of BMI with baseline demographic and intensive care unit (ICU) parameters, laboratory values, and outcomes in a critically ill patient cohort was examined.
Methods...
Objective
This study aimed to compare outcomes of treatment strategies for weight regain after bariatric surgery.
Methods
This is a retrospective analysis of 207 individuals treated for post‐bariatric weight regain at an academic center from January 1, 2014, through November 25, 2019. Percentage body weight loss was compared after 3, 6, 9, and 12 months of treatment among an intensive lifestyle...
Objective
The current study investigated associations between mothers’ and fathers’ distress reported in early childhood (at ages 9 months and 3 years) and childhood adiposity trajectories from ages 5 to 14 years.
Methods
Linear mixed‐effects models were undertaken in the Millennium Cohort Study. Self‐reported maternal and paternal distress was measured at ages 9 months and 3 years. BMI and fat...
Chronic inflammation is considered a precipitating factor and possibly an underlying cause of many noncommunicable diseases, including cardiovascular disease, metabolic diseases, and some cancers. Obesity, which manifests in more than 650 million people worldwide, is the most common chronic inflammatory condition, with visceral adiposity thought to be the major inflammatory hub that links obesity...
There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status but that is lower among normal weight individuals (about 30%) and substantially higher in the subpopulation of individuals with obesity and severe obesity (about 60%‐80%). The appreciation that heritability varies across classes of BMI represents an important advance. After controlling...
Objective
This study aimed to evaluate the effect of adiposity and fat distribution on the odds of elevated cardiovascular risk factors among adults with type 2 diabetes mellitus.
Methods
The present cross‐sectional study included 2,427 adults with type 2 diabetes mellitus. Body fat was assessed by dual‐energy x‐ray absorptiometry. Multivariate‐adjusted logistic regression was used to estimate...
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