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Objective
This study aimed to test the hypothesis that young adults with obesity and cold‐activated brown adipose tissue (BAT) are less likely to have metabolic dysfunction (dyslipidemia, insulin resistance, and hypertension) than those without cold‐activated BAT. Previous studies have noted a potentially protective effect of BAT and higher adiponectin/leptin ratios, but they have acknowledged that...
Objective
The aim of this study was to investigate whether baseline (pre–weight loss) metabolic variables can predict weight regain.
Methods
About 117 women with overweight completed a weight loss program to achieve BMI < 25 kg/m2 and were followed for 2 years. Resting metabolic rate, respiratory quotient, insulin sensitivity, and serum leptin concentration were measured pre–weight loss, while...
Objective
The aim of this study was to describe the age‐ and gender‐specific incidence of depression, the dose‐response relationship between BMI and risk of depression (Cox proportional hazards), and antidepressant drug prescribing in adults with overweight or obesity.
Methods
A retrospective electronic health record study using the Clinical Practice Research Datalink was conducted to identify...
Objective
This study aimed to assess the relationship between dopamine, a neurotransmitter involved in feeding behavior, and ad libitum energy intake in humans.
Methods
Healthy individuals (n = 158; 72 Native American, 50 white, 18 black, and 18 Hispanic participants; BMI: 33 [SD 9] kg/m2; body fat: 33% [SD 9%]) were admitted for two inpatient studies investigating the determinants of ad libitum...
Objective
Intermittent (INT) access to a high‐fat diet (HFD) can induce excessive‐intake phenotypes in rodents. This study hypothesized that impaired satiation responses contribute to elevated intake in an INT‐HFD access model.
Methods
First, this study characterized the intake and meal patterns of female rats that were subjected to an INT HFD in which a 45% HFD was presented for 20 hours every...
Objective
The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI).
Methods
MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30.3 ± 4.4 kg/m2) and controls without lipedema (n = 14, age = 42.8 ± 13.2 years, BMI = 28.8 ± 4.4 kg/m...
Medication management in children and adolescents with obesity is challenging because both developmental and pathophysiological changes may impact drug disposition and response. Evidence to date indicates an effect of obesity on drug disposition for certain drugs used in this population. This work identified published studies evaluating drug dosing, pharmacokinetics (PK), and effect in pediatric patients...
Objective
Weight regain after weight loss is common, and there is evidence to suggest negative effects on health because of weight cycling. This study sought to investigate the impact of weight regain in formerly obese mice on adipose tissue architecture and stromal cell function.
Methods
A diet‐switch model was employed for obesity induction, weight loss, and weight regain in mice. Flow cytometry...
Objective
Weight regain (WR) after Roux‐en‐Y gastric bypass surgery (RYGB) starts to occur 2 years after surgery, ultimately affecting at least 25% of patients. A limited number of studies have evaluated the impact of antiobesity medications (AOMs) on this phenomenon.
Methods
This study reviewed the electronic medical records of 1,196 patients who underwent RYGB between 2004 and 2015. WR was evaluated...
Objective
This study aimed to perform a preliminary investigation of the impact of combined hormonal contraceptive (CHC) use on weight loss during an 18‐month behavioral weight‐loss trial.
Methods
Adults (n = 170; 18‐55 years; BMI 27‐42 kg/m2) received a weight‐loss intervention that included a reduced‐calorie diet, a progressive exercise prescription, and group‐based behavioral support. Premenopausal...
The global outbreak of the 2019 novel coronavirus disease has had a tremendous psychological impact on individuals around the world. Individuals with obesity are susceptible to distress and psychological sequalae secondary to this pandemic, which can have detrimental effects on obesity management. In particular, individuals undergoing bariatric surgery could experience increased emotional distress,...
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