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Objective
This study investigated whether blood concentrations of leptin, ghrelin, and adiponectin are affected by acute total sleep deprivation in a sex‐ and weight‐specific manner.
Methods
A total of 44 participants (mean age 24.9 years; 20 women; 19 with obesity) participated in a crossover design, including one night of sleep deprivation and one night of sleep in the laboratory. After each...
Objective
The study aim was to examine the relationships between longitudinal dietary trajectories from early pregnancy to 3 years post delivery and adiposity measures in women with obesity.
Methods
The diets of 1208 women with obesity in the UPBEAT (UK Pregnancy Better Eating and Activity Trial) study were assessed using a food frequency questionnaire (FFQ) at 15+0 to 18+6 weeks’ gestation (baseline),...
Objective
High‐fat diets (HFD) are thought to disrupt energy homeostasis to drive overeating and obesity. However, weight loss resistance in individuals with obesity suggests that homeostasis is intact. This study aimed to reconcile this difference by systematically assessing body weight (BW) regulation under HFD.
Methods
Male C57BL/6 N mice were fed diets with varying fat and sugar in different...
Objective
This study assessed the effects of semaglutide on body weight, cardiometabolic risk factors, and glycemic status in individuals categorized by baseline BMI with or without additional obesity‐related comorbidities, including prediabetes and high risk of cardiovascular disease (CVD).
Methods
This was a post hoc exploratory subgroup analysis of the Semaglutide Treatment Effect in People...
Objective
The aim of this study was to evaluate the role of obstructive sleep apnea (OSA) treatment on heart remodeling and diastolic dysfunction in patients with metabolic syndrome (MS).
Methods
This study is a prespecified analysis of a randomized placebo‐controlled trial that enrolled patients with a recent diagnosis of MS and moderate‐to‐severe OSA to undergo continuous positive airway pressure...
Objective
The aim of this study was to assess the prevalence and severity of sleep‐disordered breathing (SDB) across racial/ethnic groups in 3702 pregnant people at 6 to 15 and 22 to 31 weeks gestational age, examine whether BMI modifies the association between race/ethnicity and SDB, and investigate whether interventions to reduce weight might reduce racial/ethnic disparities in SDB.
Methods
Differences...
Objective
The aim of this study was to evaluate whether short sleep duration or later sleep timing is a risk factor for insulin resistance (IR) in late adolescence.
Methods
Mexico City adolescents enrolled in a longitudinal birth cohort (ELEMENT) took part in two study visits during peri‐puberty that occurred approximately 2 years apart. IR was assessed with serum glucose and insulin. Four groups...
Objective
Up to 70% of women with polycystic ovary syndrome (PCOS) have pre‐obesity or obesity. The aim of this study was to investigate whether women with PCOS have more weight‐loss attempts than women without PCOS, regardless of BMI. Moreover, women's weight perceptions in relation to previous weight‐loss attempts were evaluated.
Methods
A population‐based birth cohort study included women with...
Objective
Metabolic reprogramming is a main feature of proinflammatory macrophage polarization, a process that leads to inflammation in dysfunctional adipose tissue. Therefore, the study aim was to explore whether sirtuin 3 (SIRT3), a mitochondrial deacetylase, participates in this pathophysiological process.
Methods
Macrophage‐specific Sirt3 knockout (Sirt3‐MKO) mice and wild‐type littermates...
Adaptive thermogenesis (AT) is the mass‐independent decrease in energy expenditure (EE) in response to caloric restriction and weight loss. AT becomes manifest throughout all periods of weight loss and persists during subsequent weight maintenance. AT occurs in resting and nonresting energy expenditure as ATREE and ATNREE, respectively. ATREE appears in different phases of weight loss, each with likely...
Objective
The goal of this study was to address the absence of evidence‐based weight‐control programs developed for use with Deaf people.
Methods
Community‐based participatory research informed the design of the Deaf Weight Wise (DWW) trial and intervention. DWW focuses primarily on healthy lifestyle and weight through change in diet and exercise. The study enrolled 104 Deaf adults aged 40 to 70...
Retraction: Hinds, T.D., Jr., Sodhi, K., Meadows, C., Fedorova, L., Puri, N., Kim, D.H., Peterson, S.J., Shapiro, J., Abraham, N.G. and Kappas, A. (2014), Increased HO‐1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. Obesity, 22: 705–712 (https://doi.org/10.1002/oby.20559).
The above article, published online on July 9, 2013, in Wiley Online Library...
Objective
The role of vascular risk factors in age‐related brain degeneration has long been the subject of intense study, but the role of obesity remains understudied. Given known sex differences in fat storage and usage, this study investigates sex differences in the association between adiposity and white matter microstructural integrity, an important early marker of brain degeneration.
Methods...
Objective
Improving mitochondrial function is a promising strategy for intervention in type 2 diabetes mellitus. This study investigated the preventive effects of sodium ferrous citrate (SFC) and 5‐aminolevulinic acid phosphate (ALA) on several metabolic dysfunctions associated with obesity because they have been shown to alleviate abnormal glucose metabolism in humans.
Methods
Six‐week‐old male...
Objective
In patients with obesity, use of positive end‐expiratory pressure (PEEP) > 5 cm H2O (centimeters of water) has been shown to prevent intraoperative atelectasis. This study compares the rate of postoperative pulmonary complications (PPCs) associated with PEEP > 5 cm H2O and PEEP ≤ 5 cm H2O in patients with obesity who underwent surgery under general anesthesia with mechanical ventilation...
Objective
The aim of this study was to investigate glucose tolerance, glucagon response, and beta cell function during a 1‐year maintenance period with either exercise, the glucagon‐like peptide‐1 receptor agonist liraglutide, or the combination after diet‐induced weight loss.
Methods
In this randomized placebo‐controlled trial, adults with obesity (BMI: 32–43 kg/m2) without diabetes underwent...
Objective
Alterations in the hepatic lipidome are a crucial factor involved in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the serum and hepatic profile of branched‐chain fatty acids (BCFAs) in patients with different stages of NAFLD.
Methods
This was a case–control study performed in 27 patients without NAFLD, 49 patients with nonalcoholic...
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