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Despite decades of progress, developing minimally invasive bone‐specific drug delivery systems (DDS) to improve fracture healing remains a significant clinical challenge. To address this critical therapeutic need, nanoparticle (NP) DDS comprised of poly(styrene‐alt‐maleic anhydride)‐b‐poly(styrene) (PSMA‐b‐PS) functionalized with a peptide that targets tartrate‐resistant acid phosphatase (TRAP) and...
Aseptic loosening of prostheses is a highly researched topic, and wear particle‐induced macrophage polarization is a significant cause of peri‐prosthetic osteolysis. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs‐Exos) promote M2 polarization and inhibit M1 polarization of macrophages. However, clinical application problems such as easy clearance and lack of targeting exist. Exosomes...
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