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The purpose of this study was to reveal the apoptotic cell formation, using histopathological and immunohistochemical methods, in non-pregnant and pregnant New Zealand White rabbits, and in offspring of the pregnant group exposed to GSM modulated signal in 1,800 MHz frequency. Apoptotic cells were detected in the brain, eyes, kidneys, liver, lung, heart, and spleen by terminal deoxynucleotidyl transferase-mediated...
The type 1 insulin-like growth factor receptor (IGF-1R), which is over-expressed or activated in many human cancers, including lung cancer, mediates cancer cell proliferation and metastasis. Several studies indicate that blocking IGF-1R expression can inhibit tumor cell proliferation and metastasis. In this study, inhibition of the endogenous IGF-1R by recombinant adenoviruses encoding short hairpin...
Experience over several years has indicated that chemotherapy, even if widely used, does not always remain effective in the therapy of lung tumours and, in addition, is linked to serious side effects. In parallel, some plant polyphenols are known to exert a proapoptotic action on tumour cells while, in contrast, representing anti-cancerogenic anti-oxidants in living organisms. Our studies were aimed...
Modifying effect of Solcoseryl upon the late postirradiation damage of the lungs expressed as the number of apoptotic cells per 1mm² of the pulmonary tissue was investigated in rats. The number of labelled apoptotic cells in situ was determined by TUNEL method under light microscope connected to computer imaging (Lucia software). The results of the experiment demonstrated statistically significant...
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