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Ceramides, bioactive members of the sphingolipids can be generated by de novo synthesis, sphingomyelin hydrolysis and by acylation of sphingosine. Ceramides are known to regulate several cellular processes, including differentiation, growth suppression, cell senescence and apoptosis. The ceramide levels increased in several pathological conditions such as brain ischemia, hypoglycemia, inflammation...
Nitric oxide (NO) is a potent extracellular and intracellular physiological messenger. However, NO liberated in excessive amounts can be involved in macromolecular and mitochondrial damage in brain aging and in neurodegenerative disorders. The molecular mechanism of its neurotoxic action is not fully understood. Our previous data indicated involvement of NO in the release of arachidonic acid (AA),...
The involvement of peroxisome proliferator-activated receptors (PPARs) in the cancer cell elimination through apoptosis is a generally accepted fact. However, some reports indicate that the activation of PPAR is directly responsible for carcinogenesis. Caco-2 cells, a human adenocarcinoma cells, were used as a model of colon cancer. Cell cultures (5x106 cell per dish) were pretreated for 24h with...
2,4-dichlorophenoxyacetic acid (2,4-D) is a herbicide commonly used in agriculture. The residues of 2,4-D are present in air, water, soil and edibles. It constitutes a real hazard for human and animal health as numerous accidents of poisoning deaths caused by this herbicide have been reported. However, the molecular mechanism of its action is still unknown. The point of view concerning the toxic action...
Pharmacological activity of garlic (Allium sativum L.) has been thoroughly evaluated for many years. The development of modern techniques in phytochemical analysis has enabled to detect a broad spectrum of organosulfur compounds which have an interesting biological activity. Recently, inhibition of carcinogenesis, observed at many stages, has seemed to be the most important feature. It has been established...
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