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If obesity were tied only to too much food or too little physical activity, the cure would be a simple matter of counting calories or keeping track of steps with a pedometer. Unfortunately, obesity is much more complex. Many other factors come into play, including so-called hunger genes that make a person more susceptible to obesity, infection with certain pathogens linked to weight gain, hormones...
This paper presents a novel approach based on the analysis of genetic variants from publicly available genetic profiles and the manually curated database, the National Human Genome Research Institute Catalog. Using data science techniques, genetic variants are identified in the collected participant profiles and then indexed as risk variants in the National Human Genome Research Institute Catalog...
This paper presents the application of an approach based on the Bayesian Networks technique to minimize nephropathy risk in type 2 diabetics. This model consists to assess risk factors of type 2 diabetes and nephropathy by using prevalence extracted from the World Health Organization statistics and the health status report of Moroccan population of 2012. This prevalence has helped to test the validity...
Objective: To reexamine literature and data on the effects of gene mutation on central precocious puberty (CPP) via a meta-analysis. Methods: Consultation of search engines Chinese Bio-medicine Database, China National Knowledge Infrastructure, Pubmed and Medline search resulted in a total of six studies containing more than 1600 individuals from various ethnic backgrounds. To evaluate the risk of...
The socioeconomic transformations in the last decades and its consequent changes to societies lifestyle have increased the incidence of chronic diseases. Genomic medicine has suggested that the exposure to risk factors since conception may influence gene expression and consequently induce the development of chronic diseases in adulthood . Scientific papers bringing up these discoveries indicate that...
Most common complex traits such as obesity, hypertension, diabetes, and cancers are known to be associated with multiple genes, environmental factors, and epistasis. Recently, the development of advanced genotyping technologies allows us to perform the genome-wide association studies (GWAS). For detecting the effects of multiple genes on complex traits, many approaches have been proposed for GWAS...
To improve our understanding of the role(s) that genes and environmental factors play in a complex disease, we need statistical approaches that model multiple factors simultaneously in a hierarchical manner that aims to reflect the underlying biological system(s). We present an approach that models genes as latent constructs, defined by multiple variants (single nucleotide polymorphisms, SNPs) within...
DNA base damage results from a combination of endogenous sources, (normal metabolism, increased metabolism due to obesity, stress from diseases such as arthritis and diabetes, and ischemia) and the environment (ingested toxins, ionizing radiation, etc.). If unrepaired DNA base damage can lead to diminished cell function, and potentially diseases and eventually mutations that lead to cancer. Sophisticated...
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