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Microvascular dysfunctions are responsible for the vascular complications of diabetes, frequently observed in obese subjects. The present study was aimed to assess microvascular skin blood flow and related oscillations in hyperglycemic obese subjects. Twenty-eight normoglycemic controls and twenty-nine hyperglycemic subjects were recruited from our Outpatient Clinics. Anthropometric measurements were...
There is a crisis that is impacting health care in the Arab nations of the Middle East and in north and west Africa: six countries in this region are on the top-ten list worldwide in terms of diabetes prevalence. Comprising 22 countries with a total population of 350 million people, these nations constitute only about 5% of the total world population. Yet, nearly 20% of the people in Kuwait, Lebanon,...
The prevalence of obesity is growing at an alarming rate, placing many at risk for developing diabetes, hypertension, sleep apnea, or a combination of disorders known as “metabolic syndrome”. The evidence to date suggests that metabolic syndrome results from an imbalance in the mechanisms that link diet, physical activity, glucose-insulin control, and autonomic cardiovascular control. There is also...
The Purpose of this research is to discuss the function mechanism of raspberry ketone on simple obesity and the influence of resistance on obesity relevant insulin. There were 40 SD rats of SPF grade, and the male to female ratio was 1:1. They were randomly divided into 5 groups: NC fed with normal diet. MC fed with high-fat diet. RKL, RKM, and RKH groups fed with high-fat diet and were administered...
Obesity is the final consequence of a chronic positive energy balance in adipocytes,and it is a major risk factor for insulin resistance,type 2 diabetes mellitus,and many other lifestyle-related diseases.Adipose tissue can sense the energy status and signals other organs with adipokines.Insulin resistance is closely associated with inflammatory adipokines and oxidative stress in adipose tissue. However,...
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and leptin signaling, and is therefore a major molecular target for the treatment of type II diabetes and obesity. WPD loop is a key element in the mechanism of PTP1B catalysis. In the apo form, WPD loop is usually in an “open” conformation, whereas it closes over the active site upon substrate binding. Here, targeted molecular...
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