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This article presents an application of modified local search (MLS) to design meal's plan for obestity by food exchange list. Both computational experiment and implementation are elaborated. Three obesity cases have been tested with 10 independent trials. The minimum searching time of case I, II, and III are 0.1784, 0.0384 and 0.0784 seconds, respectively. An implementation has selected an obtained...
Overweight and obesity are the fifth risk factor for overall mortality. At least 2.8 million adults die each year as a result of their being overweight or obese. According to WHO, the prevalence of obesity has doubled since 1980 until now. In 2014, over 1.4 billion adults aged over 20 years were overweight. In the Department of Health and Human Development, "Stefan cel Mare" University of...
Objective: To understand the research hotspots of C-reactive protein by PubMed. Methods: With MS Excel, SPSS, Cytoscape software, we took MeSH (Medical Subject Headings) word frequency analysis, clustering analysis, co-word network graph of PubMed papers. Results: It shows that the current C-reactive protein research hotspots had focus on "Inflammation, Cardiovascular Diseases, Biological Markers,...
The primary objective is to manage weight and body composition through a mobile phone app utilizing a personalized self-adapting metabolic health monitoring system and a web based interactive technology with practitioner coaching for lifestyle changes. A mathematical model of the energy metabolism has been developed based on the principle of the conservation of energy to estimate the daily utilized...
Childhood is a dynamic period of life that rapid growth and development take place. Making mistakes in feeding practices of children may lead to undesirable consequences like malnutrition and obesity. Use of an automated computer-based technique to assist determination of daily dietary requirements of energy, protein and water has potential for preventing malnutrition and obesity. To get the solution...
Objective: To reexamine literature and data on the effects of gene mutation on central precocious puberty (CPP) via a meta-analysis. Methods: Consultation of search engines Chinese Bio-medicine Database, China National Knowledge Infrastructure, Pubmed and Medline search resulted in a total of six studies containing more than 1600 individuals from various ethnic backgrounds. To evaluate the risk of...
It is well-known that obesity has a marked effect on many of the routinely used laboratory parameters. An obvious example is the serum level of various blood lipids: hyperlipidemia, hypercholesteremia are often observed in obese people. Our research aimed to provide a more thorough understanding of the effects of obesity on laboratory parameters, concentrating on every laboratory parameter, not just...
In recent years the effects of industrial growth have resulted in drastic changes in consuming behavior, standard of living, and lifestyles. In particular there has been a significant rise in the number of people who eat out regularly. This often means that they cannot control the characteristics of the food they take, such as its taste, calories per portion, and other nutritional details. As a result...
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and leptin signaling, and is therefore a major molecular target for the treatment of type II diabetes and obesity. WPD loop is a key element in the mechanism of PTP1B catalysis. In the apo form, WPD loop is usually in an “open” conformation, whereas it closes over the active site upon substrate binding. Here, targeted molecular...
In this article, the most commonly used body composition methods for the assessment of whole-body and segmental-body compartments, including fat mass (FM), fat-free mass (FFM), total body water (TBW), extracellular water (ECW), intracellular water, bone mineral content, protein mass, and body cell mass (BCM), were described. A basic description of each method including theoretical principles, applications,...
AMP-activated protein kinase (AMPK) is a metabolite- sensed protein kinase in various eukaryotes. The activated AMPK regulates important proteins which cause diabetes, obesity, metabolic aberrant, and also breast cancer. In this study, the yeast AMPK structure was used as a template to model the human AMPK structure. By homology modeling, the reliable AMPK structure was built, and the active binding...
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