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AbstractAims/hypothesis. To determine whether genetic variation in uncoupling protein-1 (UCP-1) is associated with obesity or obesity-related risk factors in overweight women.Methods. We genotyped 526 overweight/obese women (mean body mass index 34.1 kg/m2, range 25.0 to 47.5 kg/m2) for the 3826 AG uncoupling protein-1 polymorphism. Of the 526 women genotyped 144 had fasting blood samples analysed...
Summary To assess the role of polymorphisms in the β2-adrenergic receptor gene in the development of obesity and obesity-related metabolic disorders, we analysed Arg16Gly, Gln27Glu, and Thr164Ile polymorphisms in 400 non-obese subjects (body mass index < 27 kg/m2) and 108 obese subjects (body mass index ≥ 27 kg/m2). The Gln27Glu substitution was twice as common in obese subjects as in non-obese...
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