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We have investigated functional connectivity of the default mode network (DMN) in normal aging and Alzheimer's disease (AD) using resting state fMRI at 3T. Images from young and elderly controls, and patients with AD were processed using spatial independent component analysis to identify the DMN. Functional connectivity was quantified using integration and indices derived from graph theory. Four DMN...
Cognitive, motor and perceptual processes diminish with age and thus limit adaptive capabilities of older individuals. Our hypothesis is that with aging there is decreased expression of these proactive adaptive capabilities. These experiments were designed to test this hypothesis by implementing an integrated approach to quantifying physiological characteristics in older individuals. We are working...
Objective: Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects. Methods: Eighty-seven depressed subjects and 47 control subjects underwent 1.5 T cranial magnetic resonance imaging (MRI). Utilizing a semiautomated method, a segmented image...
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