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Late-life depression is characterized by both lower mood and poor cognitive performance, symptoms that often do not fully respond to current antidepressant medications. Nicotinic acetylcholine receptor (nAChR) agonists such as nicotine may serve as a novel therapeutic approach for this population. Both preclinical and preliminary clinical studies suggest that nAChR agonists can improve depressive...
Populations of healthy older individuals are often highly heterogeneous, as prevalence of various underlying pathologies increases with age. Finding coherent groups of normal older adults may allow to identify subpopulations that are at risk of developing Alzheimer's disease (AD). In this paper, we propose an approach that utilizes longitudinal magnetic resonance imaging (MRI) data to obtain natural...
We investigated age-related changes in the semantic distance between successively generated words in two letter fluency tasks differing with respect to demands placed on executive control. The semantic distance was measured by Latent Semantic Analysis (LSA). The results show that older people have a larger semantic distance between successively generated items than young people, and that this effect...
This poster aims to give an overview of the concept behind a project called Vital Mind, which is investigating the user design and technical challenges to facilitate the delivery of cognitive training to older people via interactive digital television.
Evaluation of cognitive function is an important tool in clinical care. A novel method of cognitive monitoring is proposed, whereby subjects complete three sessions of the popular past-time Sudoku while EEG is recorded. Data epochs surrounding a correct solution are extracted and compared to a resting condition. Mean EEG amplitude in the alpha and theta bands are examined by means of the temporal...
Balance and locomotion involve multi-sensory integration while meeting environmental demands. In addition, increased task complexity negatively affects postural control in aging and patient populations. The goal of this pilot study was to examine the effects of aging and cognitive load on the visual perception of vertical. Four young and 3 older individuals participated. Subjective visual vertical...
Cognitive, motor and perceptual processes diminish with age and thus limit adaptive capabilities of older individuals. Our hypothesis is that with aging there is decreased expression of these proactive adaptive capabilities. These experiments were designed to test this hypothesis by implementing an integrated approach to quantifying physiological characteristics in older individuals. We are working...
Americans are living longer, and research shows that seniors are embracing independence, and will benefit from living in the same place. These are the rationale for 'Aging in Place' and the development of Tiger Place, an 'Aging in Place' Environment in Columbia Missouri. Our goal is to minimize intrusion, allow the resident complete control over privacy and treatment (if any), and to provide substantive...
Americans are living longer, and research shows that seniors are embracing independence, and will benefit from living in the same place. These are the rationale for 'Aging in Place' and the development of Tiger Place, an 'Aging in Place' Environment in Columbia Missouri. Our goal is to minimize intrusion, allow the resident complete control over privacy and treatment (if any), and to provide substantive...
The existing paradigm of ongoing or posttreatment monitoring of patients through periodic but infrequent office visits has many limitations. Relying on self-report by the patient or their family is equally unreliable. We propose an alternative paradigm in which continuous, unobtrusive monitoring is used to observe changes in physical behavior over time. We highlight the use of this technique for monitoring...
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