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Folate is an important B vitamin required for methylation reactions, nucleotide and neurotransmitter synthesis, and maintenance of homocysteine at nontoxic levels. Its metabolism is tightly linked to that of choline, a precursor to acetylcholine and membrane phospholipids. Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T...
S-adenosylmethionine (SAM) is a sulfur-containing molecule at the heart of metabolism of all organisms. It is well known as the methyl donor for the majority of methyltransferases that modify DNA, RNA, histones, and many other proteins such as Tp53, lipids, and a variety of other small molecules including toxic compounds, such as arsenic, whose actions affect replication, transcription,...
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