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Background Alterations to cellular and molecular programs with brain aging result in cognitive impairment and susceptibility to neurodegenerative disease. Changes in DNA methylation patterns, an epigenetic modification required for various CNS functions are observed with brain aging and can be prevented by anti-aging interventions, but the relationship of altered methylation to gene expression is...
Polycomb group (PcG) members are the key components of the cellular machinery that maintains the expression state of a large number of genes right from the early development through the entire life span of an individual. This evolutionarily well–conserved group of proteins create and maintain epigenetic chromatin marks that are translated into means of maintaining a temporally and spatially regulated...
Regulation of serine racemase (SR) occurs at transcriptional and translational levels; post-translational modification, cytosolic distribution as well as allosteric effect regulate SR activity. In this study, we report a new route of SR regulation, i.e. oxidative stress and hypermethylation of the srr (gene of SR) promoter correlate with its reduced transcription in aging rat cerebella. We first showed...
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