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Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and...
This chapter contains sections titled:
Introduction
The Cancer‐Prone Metabolic Phenotype of Aging
Age‐Related Epigenetic Silencing Via DNA Methylation
Inflammatory Control of Age‐Related Epigenetic Regulators
Lessons from Anti‐Aging Modalities
Conclusions
References
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