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Polycomb group (PcG) members are the key components of the cellular machinery that maintains the expression state of a large number of genes right from the early development through the entire life span of an individual. This evolutionarily well–conserved group of proteins create and maintain epigenetic chromatin marks that are translated into means of maintaining a temporally and spatially regulated...
Protection of the transcriptional “stemness” network is important to maintain a healthy hematopoietic stem cells (HSCs) compartment during the lifetime of the organism. Recent evidence shows that fundamental changes in the epigenetic status of HSCs might be one of the driving forces behind many age-related HSC changes and might pave the way for HSC malignant transformation and subsequent leukemia...
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