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According to the “Developmental Origins of Health and Disease” (DOHaD) concept, the early-life environment is a critical period for fetal programming. Given the epidemiological evidence that air pollution exposure during pregnancy adversely affects newborn outcomes such as birth weight and preterm birth, there is a need to pay attention to underlying modes of action to better understand not only these...
Aging is a complex biological process that manifests through cellular, physical, and metabolic changes in all types of tissues. Changes in chromosome structure and function throughout life play a pivotal role in this irreversible physiological process by affecting gene expression, replication, recombination, DNA repair, and epigenetic programming. Upon exogenous stress or simply as the result of cellular...
Humans display a large inter-individual variation in leukocyte telomere length (LTL), which is influenced by heredity, sex, race/ethnicity, paternal age at conception and environmental exposures. LTL dynamics (birth LTL and its age-dependent attrition thereafter) mirror telomere dynamics in hematopoietic stem cells (HSCs). LTL at birth is evidently a major determinant of LTL throughout the human lifespan,...
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