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In this paper, a simple method for cell dipping in a microfluidic device using dielectrophoresis is presented. A microfluidic system includes glass substrate and PDMS element is fabricated and tested. Cells dipping is performed and achieved using two sets of electrodes that slightly protrude into the microchannel through the sidewalls. The fabrication process and testing of the device are detailed.
Microfluidic devices depend on the miniaturization of some components such as sensors, actuators and reactors to enable its applications and expand the possibilities. In this context, we fabricated an actuator capable of pumping fluids through microchannels and ensure the portability of the microfluidic device. The actuator uses the magnetic field generated by a coil to move a neodymium magnet over...
In this study, we present a smooth enucleation process on a microfluidic chip. To improve the success rate of enucleation and increasing the potential viability of the enucleated oocyte, a microfluidic system is specially designed. Magnetically driven MicroTool (MMT) control the flow distribution in the microchamber. Designed microchannel with height difference is for the purpose of confining oocyte...
We present a continuous enucleation process of bovine oocytes on a microfluidic chip to achieve the continuous cutting of the oocytes and increasing the potential viability of the enucleated oocyte. By combining microfluidic chip and micororobotics, the flow in a channel can be actively controlled and we achieved successive operations of 1) loading oocyte, 2) control cutting volume and 3) removing...
In this paper we propose the modeling and simulation using Comsol 3.5a of a microfluidic chip, capable to run several tasks such as focusing, mixing, sorting and trapping nano and microbeads. The microfluidic chip, based on Polydimethyl siloxane (PDMS) and Polyethylenenaphtalate (PEN), is cost effective, flexible and totally biocompatible. The fluidic part is controlled both by pressure driven flow...
A parallel laminar micromixer with staggered curved channels is designed and fabricated in our study. The split-and-recombination (SAR) structures of the flow channels result in the reduction of the diffusion distance of two fluids. Furthermore, the impinging effects increase the mixing strength whereas one stream is injected into the other. The particles trajectories are utilized to numerically examine...
A particle manipulating micromixer was developed successfully in this study. The present device was fabricated by simply MEMS process. Only two photomasks, one for electrode array chip and another for micro-channel, were needed to manufacture the micromixer. Dielectrophoresis (DEP) force was used to manipulate the particles in the micro-channel. In this experience, polymer particles with diameter...
Heat transfer due to forced convection caused by acoustic streaming in microfluidic devices is shown to have potential in cooling effect. However, few studies are made for theoretically studying the fluid motion induced by the acoustic field and forced heat transfer for micro cooling in microdevices. In this paper, Navier-Stokes equations are first employed to study acoustic radiation force and acoustic...
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