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In summary, the recent increase in the knowledge of the signaling mechanisms in the circadian axis along with a fuller understanding of the interaction of the epidermal growth factor receptor (EGFR) family of ligands and how they can interact with the brain have led to a new hypothesis that the symptom complex of fatigue, poor appetite, and sleep disruption in cancer patients are related to altered...
One of the most common symptoms in cancer patients is fatigue that is often associated with appetite loss and sleep disruption. Quality of life indices and objective measures of these symptoms are now possible and continue to improve our understanding of how these symptoms are caused. Disruption of 24 hour rest/activity patterns measured by actigraphy is one example where there is overlap of the objective...
One of the most common symptoms in cancer patients is fatigue that is often associated with appetite loss and sleep disruption. Quality of life indices and objective measures of these symptoms are now possible and continue to improve our understanding of how these symptoms are caused. Disruption of 24 hour rest/activity patterns measured by actigraphy is one example where there is overlap of the objective...
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