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The effectiveness of an imaging technique is often based on the ability to image quantitatively both morphological and physiological functions of the tissue. Here we present several ultrasound-based imaging techniques capable of visualizing both structural and functional properties of living tissue. Each imaging system utilizes custom-made, targeted nanoparticles developed to probe specific molecular...
Prostate cancer (PCa) remains a major health concern in many countries. However, it cannot be imaged reliably by any commonly used imaging modality. Therefore, needle biopsies and treatments cannot be targeted to suspicious regions. Our objective is to develop and test an ultrasonic method based on spectrum analysis of radio-frequency (RF) ultrasound echo signals and on classification using current...
Background and Objective: Augmentation of local drug delivery from targeted nanoparticles (NP) with nondestructive, noncavitational clinical ultrasound (US) offers the potential to enhance therapeutic efficacy in diseases such as cancer while limiting adverse systemic side effects. This lab has demonstrated augmentation of drug delivery from alphavbeta3-targeted perfluorocarbon NP and US in cancer...
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