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This in this paper we present the design of the foundation of an expert system for clinical interpretation of the “-omics” data using methods of big data processing. Such an expert system should be able to classify tumors processing vast volume of input data of different nature (demographic, genomic, clinical, epidemiological, diagnostic) and to be ready to append data in real-time, to update itself,...
An adaptive fuzzy c-means (AFCM) clustering based algorithm was developed and applied to the segmentation and classification of multi-color fluorescence in situ hybridization (M-FISH) images, which can be used to detect chromosomal abnormalities for cancer and genetic disease diagnosis. The algorithm improves the classical fuzzy c-means (FCM) clustering algorithm by introducing a gain field, which...
Irinotecan has been proven to have anti-tumor effects and is used for chemotherapy in colorectal cancer. It is a prodrug converted by carboxylesterase to form the active metabolite 7-ethyl-10-hydroxy-camptothecin (SN38). To identify the potential molecular function of SN38 in colon cancer, we investigated the gene expression profile of colon cancer cell lines treated with SN38 and tried to reveal...
CpG islands (CGIs) play a fundamental role in genome analysis as genomic markers and tumor markers. Identification of potential CGIs has contributed not only to the prediction of promoters of most house-keeping genes and many tissue-specific genes but also to the understanding of the epigenetic causes of cancer. The most current methods for identifying CGIs suffered from various limitations and involved...
Expressed sequence tags (ESTs) are single-pass sequence reads from cDNA clones. ESTs usually represent genes expressed in a particular tissue. Single nucleotide polymorphism (SNP) is a very important resource for protein structure and function. It may make a contribution to understand a complex disease, such as tumor. Through analysis of large scale human ESTs, we try to find relationship among SNPs,...
Microarray is widely used for the cancer research and identifies different expressions for specific genes. We present a computational method for constructing cancer and normal gene regulatory networks from micorarray data based on transcription factor analysis and independency test. The web service technology is used to wrap the bioinformatics toolkits of methods and databases to automatically extract...
Information privacy typically concerns the confidentiality of personal identifiable information (PII) and protected health information (PHI) such as electronic medical records. Thus, the information access control mechanism for e-health services must be embedded with privacy-enhancing technologies. Role-based access control (RBAC) model has been widely investigated and applied to various applications...
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