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Alopecia areata (AA) is a common and stressful disorder that results in hair loss, and resistant to treatment in some cases. Experimental and clinical evidence suggests that AA is caused by autoimmune attack against the hair follicles. The precise pathomechanism, however, remains unknown. Here, we focus on the recent progress in multidisciplinary approaches to the epidemiology, pathogenesis, and new...
Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by hyperglycaemia secondary to inadequate production of insulin by the pancreas. This is the result of T cell-mediated autoimmune destruction of the insulin-producing β cells in the islets of Langerhans, and is associated with circulating autoantibodies to β-cell antigens. The classic clinical presentation of T1DM is an acute onset...
Lipton RB, Drum ML, Danielson KK, Greeley SAW, Bell GI, Hagopian WA. Onset features and subsequent clinical evolution of childhood diabetes over several years.
Aim: To explore whether it is possible to predict a child's eventual diabetes phenotype using characteristics at initial presentation, we reassessed 111 young patients on average 7.8 ± 4.2 (2.2–19.7) [mean ± SD (range)] years after diagnosis...
Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by hyperglycaemia secondary to inadequate production of insulin by the pancreas. This is the result of T cell-mediated autoimmune destruction of the insulin-producing β cells in the islets of Langerhans, and is associated with circulating autoantibodies to β cell antigens. The classic clinical presentation T1DM is an acute onset of...
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