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Iron oxide nanoparticles(Fe3O4 NPs) have recently received increasing interest in the biotechnology and life science. However, little is known about the nanoneurotoxicity of Fe3O4 NPs following exposure to neurons. This study was to elucidate the cytotoxicity and its mechanism of Fe3O4 NPs on PC12 cells line which derived from Rattus norvegicus pheochromocytoma. The cell viability was observed by...
Toxicity of nanomaterials has been assessed by a number of ways, but nano-toxicity standards for biosafety or environment safety have not been established worldwide. It is likely that the final "standard approaches" shall include several components such as cytotoxicity, animal organ injury and body clearance of nanoparticles, while perturbed DNA replication fidelity resulted from nanomaterials...
Carbon nanotubes represent a new class of gene transporters potentially useful for future in vitro and in vivo gene delivery applications. The aim of this study was to modify the surfaces of carbon nanotubes (CNTs) with polyamidoamine dendrimer (PAMAM) in order to reduce the cytotoxicity and enhance the cellular uptake of the nanoparticles. In this study, we have prepared and characterized the PAMAM...
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