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Background
Allergic rhinitis (AR) is a chronic inflammatory disease of the upper airway, which progresses into allergic asthma (AA) in up to 45% of children. This analysis aimed to investigate clinical and economic benefits of sublingual allergen immunotherapy (SLIT tablets) initiated early in childhood for the treatment of AR by quantifying the long‐term reduction in new cases of AA.
Methods
A...
Introduction
In allergic asthma patients, one of the more common phenotypes might benefit from allergen immunotherapy (AIT) as add‐on intervention to pharmacological treatment. AIT is a treatment with disease‐modifying modalities, the evidence for efficacy is based on controlled clinical trials following standardized endpoint measures. However, so far there is a lack of a consensus for asthma endpoints...
Background
Cost‐effectiveness studies evaluating allergen immunotherapy (AIT) in children are limited but needed to drive clinical and policy‐making decisions such as reimbursement of new interventions. In this study, we compared the cost effectiveness of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) tablets to the standard of care (SOC) treatment in children with house dust mite‐driven...
Background
Whether Dermatophagoides pteronyssinus (Der‐p) allergen immunotherapy (AIT) can induce Dermatophagoides farina (Der‐f)‐specific immunoglobulin (sIg) G4 production, and tolerance to environmental allergens has not been fully investigated.
Objective
We aimed to determine serum Der‐p‐sIgG4 and Der‐f‐sIgG4 levels in asthma and/or rhinitis patients undergoing Der‐p AIT and their ability to...
Background
Allergen immunotherapy (AIT) is a disease‐modifying treatment for IgE‐mediated diseases. Randomized controlled trials (RCTs) support AIT's potential role in asthma prevention but evidence from non‐randomized studies of interventions (NRSI) and longitudinal observational studies has been poorly addressed. Therefore, we aimed to conduct a systematic review and meta‐analysis to assess clinical...