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The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million people with diabetes in 2013, expected to rise to 592 million by 2035. The aetiological classification of diabetes has now been widely accepted. Type 1 and type 2 diabetes are the two...
Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by hyperglycaemia secondary to inadequate production of insulin by the pancreas. This is the result of T cell-mediated autoimmune destruction of the insulin-producing β cells in the islets of Langerhans, and is associated with circulating autoantibodies to β-cell antigens. The classic clinical presentation of T1DM is an acute onset...
Aims/hypothesis Type 1 diabetes is the most frequent endocrine disease in children, with 65,000 children diagnosed worldwide every year. Up to 80% of these children present with diabetic ketoacidosis (DKA), which is associated with both short-term risks and long-term consequences. This study aimed to characterise the worldwide variation in presentation of type 1 diabetes to inform future interventions...
Diabetes mellitus is a chronic disorder of glucose metabolism with serious clinical consequences. The multi-system complications of diabetes include microvascular (retinopathy, nephropathy, neuropathy) and macrovascular (ischaemic heart disease, stroke, peripheral vascular disease) endpoints. The prevalence of diabetes has been rising in the last few decades, fuelled by the global rise in the prevalence...
Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by hyperglycaemia secondary to inadequate production of insulin by the pancreas. This is the result of T cell-mediated autoimmune destruction of the insulin-producing β cells in the islets of Langerhans, and is associated with circulating autoantibodies to β cell antigens. The classic clinical presentation T1DM is an acute onset of...
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