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Essentially all asthmatics demonstrate a marked sensitivity to inhaled methacholine and histamine, termed non-specific bronchial (airway) hyperresponsiveness (BHR). Airway hyperresponsiveness is a characteristic not only of asthmatics, but can be found in many persons with allergic rhinitis as well as in members of asthmatics' families. The presence of BHR usually precedes the development of clinically...
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