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The use of two different polyclonal, affinity-purified, monospecific antibodies to ANG II (called BODE and BODE 1) revealed dissimilar distribution of ANG II immunoreactivity within the rat central nervous system (CNS). The ANG II-like material detected using BODE was concentrated in the neurosecretory hypothalamic nuclei, in the inner layer of the median eminence and in the posterior lobe of the...
Astrocytes are the major population of glial cells, and are key players in the development, maintenance, and functioning of the central nervous system (CNS). Their potential as targets of therapeutic intervention following CNS injury makes the elucidation of their cellular and subcellular physiology a primary research goal. Well defined and pure cell culture systems are required to examine astrocytic...
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