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Although the apolipoprotein E (APOE) ɛ4 allele is a major genetic risk factor for Alzheimer’s disease (AD), it is not clear whether this relationship persists among the oldest old. Several European studies suggest that the effect of the APOE ɛ4 allele on dementia and mortality disappears in very old age. We describe the APOE allele and genotype frequencies and examine whether the presence of the APOE...
The most common apolipoprotein E (APOE) allelic variation is implicated in many age-related diseases and human longevity with controversial findings. We investigated the effect of APOE gene polymorphism on all-cause mortality in elderly patients taking into consideration the functional disability, cognitive impairment, malnutrition, and the occurrence of common age-related diseases. APOE genotypes...
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