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Thromboembolic disorders—stroke and venous thromboembolism (VTE)—pose a substantial risk for mortality and morbidity. Primarily affecting individuals with atrial fibrillation (AF) in their 7 th and 8 th decades of life, these disorders will represent a growing burden as aging baby boomers expand the pool of at-risk patients in coming decades, underscoring the need for effective, well...
Vitamin K antagonists are effective oral anticoagulants, but they have limitations related to a narrow therapeutic range, food and drug interactions, slow onset of action and the need for routine coagulation monitoring. Ximelagatran is a promising new oral anticoagulant under investigation in advanced clinical trials. It is a prodrug that is converted after oral administration to melagatran, a direct...
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