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Prostate cancer (PCa) is the most commonly diagnosed cancer and the second cause of cancer deaths in American men. PCa has a relatively low progression rate, yet it cannot be cured once metastasized. The accurate diagnosis of the aggressive PCa is critical for the survival of PCa patients. Prostate biopsy is the standard procedure for evaluating the presence and aggressiveness of PCa. The microarchitecture...
Background Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically are centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were significantly associated with poor overall survival of mCRPC patients. In this study, we evaluated if miR-375 induced chemo-resistance to docetaxel through regulating target genes associated...
Prostate cancer (PC) depends on androgenic signaling for growth and survival. To data, the exact molecular mechanism of hormone controlling proliferation and tumorigenesis in the PC remains unclear. Therefore, in this study, we explored the differentially expressed genes (DEGs) and identified featured genes related to hormone stimulus from PC. Two sets of gene expression data, including PC and normal...
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