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Activation of the nuclear factor-κB (NF-κB) pathway is central to the pathogenesis of lung injury and inflammation. We determined whether targeted overexpression of inhibitor-κBα (IκBα) in the lung could decrease the severity of ventilator-induced lung injury (VILI). Anaesthetized adult male Sprague–Dawley rats were randomly allocated to undergo intratracheal instillation of: (i) vehicle alone...